Spatial transcriptomics of mammalian tissues

Prof. Shalev Itzkovitz

Department of Molecular Cell Biology, Weizmann Institute of Science


Mammalian tissues are composed of repeating anatomical units that are polarized by morphogens or directional blood flow. As a result, cells at different tissue coordinates sub-specialize in distinct physiological functions, a phenomenon termed ‘zonation’. I will describe approaches based on single cell RNA sequencing, single molecule transcript imaging and spatial transcriptomics to characterize zonation in the key metabolic organs – the liver and intestine. I will discuss emerging design principles that facilitate optimal organ function through spatial division of labor. I will also describe the impact of zonation on diverse pathological states.


日時: 2022年3月10日(木) 16:00~17:30
場所: Zoom
連絡先: 理学系研究科 生物科学専攻 生物情報科学科
黒田 真也(skuroda AT bs.s.u-tokyo.ac.jp)

info.kuroda-lab [at] bs.s.u-tokyo.ac.jp