Spatial transcriptomics of mammalian tissues
Prof. Shalev Itzkovitz
Department of Molecular Cell Biology, Weizmann Institute of Science
[Abstract]
Mammalian tissues are composed of repeating anatomical units that are polarized by morphogens or directional blood flow. As a result, cells at different tissue coordinates sub-specialize in distinct physiological functions, a phenomenon termed ‘zonation’. I will describe approaches based on single cell RNA sequencing, single molecule transcript imaging and spatial transcriptomics to characterize zonation in the key metabolic organs – the liver and intestine. I will discuss emerging design principles that facilitate optimal organ function through spatial division of labor. I will also describe the impact of zonation on diverse pathological states.
Date： Mar. 10, 2022 (Thu) 16:00 – 17:30
Place： Zoom
Host： Shinya Kuroda
If you would like to attend, please email us at info.kuroda-lab [at] bs.s.u-tokyo.ac.jp and we will send you the Zoom URL. Please use your institution’s e-mail address and let us know your name and affiliation.