Spatial transcriptomics of mammalian tissues

Prof. Shalev Itzkovitz

Department of Molecular Cell Biology, Weizmann Institute of Science



Mammalian tissues are composed of repeating anatomical units that are polarized by morphogens or directional blood flow. As a result, cells at different tissue coordinates sub-specialize in distinct physiological functions, a phenomenon termed ‘zonation’. I will describe approaches based on single cell RNA sequencing, single molecule transcript imaging and spatial transcriptomics to characterize zonation in the key metabolic organs – the liver and intestine. I will discuss emerging design principles that facilitate optimal organ function through spatial division of labor. I will also describe the impact of zonation on diverse pathological states.


Date: Mar. 10, 2022 (Thu) 16:00 – 17:30
Place: Zoom
Host: Shinya Kuroda

If you would like to attend, please email us at info.kuroda-lab [at] bs.s.u-tokyo.ac.jp and we will send you the Zoom URL. Please use your institution’s e-mail address and let us know your name and affiliation.