| The recent completion of the 34 Mb genomic sequence of Dictyostelium has facilitated expression analyses aimed at recognizing transcriptional patterns during growth and development. Synchronous development throughout the 24 hour cycle leading to fruiting body formation has permitted high resolution microarray-based studies to discover genes that define at least 6 stages. Characterization of the expression profiles of mutant strains lacking one or more critical gene products has demonstrated a dependent sequence that regulates the modules. Microarray studies using RNA isolated from each of the two major cell types, prespore and prestalk cells, has uncovered a large number of co-regulated cell-type specific genes, 150 of which have been confirmed by in situ studies carried out in collaboration with the laboratory of Mineko Maeda at Osaka University. We are now experimentally exploring shared cis-regulatory sites so that the biophysical parameters of the regulatory components can be used in predictive systems analyses. |
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Undergraduate Program for Bioinformatics and Systems Biology, |
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Graduate School of Information Science and Technology |
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Date： |
Oct 14 (Thu) |
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Time： |
3:30 - 5:00 pm |
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Place： |
Room 150, Faculty of Science, old bldg 1. |
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Host： |
Shinya Kuroda (ext 24697) |
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| Note that this seminar accompanies another seminar (II) by Prof. Stanislas Leibler
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