CREST Symposium The 1st International Symposium for Trans-Omics Location: Koshiba Hall - Hongo Campus, the University of Tokyo (map) Date: 21−22 Nov. 2017, JST Registration Fee: free Registration Form: the registration was closed Abstract: The life system is a "trans-omic" network, consisting of interactions between numerous molecules across multi-omic layers, such as genome, transcriptome, proteome, and metabolome. Lifestyle diseases can be regarded as complex multifactorial diseases caused by breakdowns in a trans-omic network rather than breakdown of a single molecule. In spite of recent advances in measurement and analysis methods for single-omic layers, trans-omic analyses integrating multi-omic data have still been in a state of the art and under development. Here we hold this symposium to shed light on strategies and obstacles in integrating multiple omic layers to establish trans-omic approaches, and to have a discussion with cutting edge researchers in omics research fields. Furthermore, we propose "human whole body transomics", integrating trans-omic analyses for human whole organs, as an international milestone for rapid expansion of trans-omic approaches. Other photos

Program Day 1, 21st November Opening remarks 13:00–13:10 Tadashi Yamamoto - Research Supervisor, CREST Session I 13:10–13:50 Nathan E. Lewis - UCSD, USA A multi-omics elucidation of the systemic regulation of metabolism through post-translational modifications 13:50–14:20 Fumio Matsuda - Osaka Univ., Japan Trans-omic analysis of the central metabolism of Saccharomyces cerevisiae by integration of metabolite concentration, metabolic flux, and enzyme abundance data Session II 14:40–15:10 Katsuyuki Yugi - RIKEN, Japan Trans-omic analysis reveals fed and fasting insulin signal across phosphoproteome, transcriptome, and metabolome 15:10–15:40 Mariko Okada - Osaka Univ., Japan Trans-Omics analysis of NF-κB regulation 15:40–16:10 Tatsuhiko Tsunoda - Tokyo Medical & Dental Univ., Japan Trans-omic analysis drives precision medicine Session III 16:30–17:00 Takeshi Bamba - Kyushu Univ., Japan Development of next generation metabolome analysis technologies for trans-omics 17:00–17:30 Tomoyoshi Soga - Keio Univ., Japan Multi-omics reveals MYC as a master regulator of colorectal cancer metabolism Keynote 17:30–18:20 Jens Nielsen - Chalmers Univ. of Technology, Sweden Quantifying Global Rewiring of Metabolism in Cancer through Genome Scale Modeling Day 2, 22nd November Session IV 9:00–9:30 Yibo Wu - RIKEN, Japan Systems proteomics of liver mitochondria activity 9:30–10:00 Hiroyuki Kubota - Kyushu Univ., Japan Trans-omic analysis of the acute insulin action in the liver -Toward in vivo trans-omic analysis 10:00–10:30 Takashi Ito - Kyushu Univ., Japan Epigenome sequencing methods for comprehensive analysis of in vivo protein-DNA interactions and DNA methylation Session V 10:50–11:30 Sarah-Maria Fendt - VIB, Belgium Nutrient metabolism – A driver of cancer 11:30–12:00 Yutaka Suzuki - Univ. of Tokyo, Japan Multi-omics analysis of cancer cells Special lecture 13:30–14:00 Craig Mak - Cell Systems, Editor Perspectives on Publishing with Cell Systems Keynote 14:00–14:50 David E. James - Univ. of Sydney, Australia Metabolic Cybernetics Session VI 15:10–15:40 Kei-ichi Nakayama - Kyushu Univ., Japan Next-generation proteomics unveils a global landscape of cancer metabolism 15:40–16:10 Shinya Kuroda - Univ. of Tokyo, Japan Trans-omic analysis of the liver of lean and obese mice during an oral glucose administration Closing remarks 16:10–16:20 Shinya Kuroda - Univ. of Tokyo, Japan Contact information Department of Biological Sciences, Graduate School of Science, University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Shinya Kuroda Tel: +81 3-5841-4699 Mail: hatano_AT_bs.s.u-tokyo.ac.jp (Personal: Hatano) Replace _AT_ with @.