.
Cellular signaling networks have evolved to relay the information
about changes in the cell microenvironment and enable adequate and
effective decision making, ensuring cell and organismal survival. We
now know that there is a considerably variety in the complexity of
signaling pathways and networks, but have a relatively limited
understanding what signal transfer and processing capabilities they
have and what emergent properties their complexity may engender. In
this talk I will demonstrate that major insights into a singling
network structure and function can arise from a systems analysis,
combining state-of-the-art experimental techniques and modeling
approaches. In particular, I will illustrate how this has been
achieved in the study of the Tumor Necrosis Factor signaling pathways,
from the first glimpses of understanding the complex dynamics of
response to very sophisticated recent analysis of the information
transfer properties. I will attempt to generalize this and other
examples into a vision of how systems biology can endow our analysis
of biological phenomena with a new meaning and make biology a truly
quantitative, analytical science.
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Seminar |
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Date： |
January27, 2012(Fri.) 16:30～18:00 |
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Place： |
Faculty
of Science Bldg.3, 4F, room 412 |
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Host： |
Shinya
Kuroda(skuroda AT bi.s.u-tokyo.ac.jp) |
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