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Protein synthesis is one of the most fundamental biochemical processes, necessary for growth but also for regulation. Molecular biology has revealed a large number of details of the protein synthesis apparatus, including ribosome structure. However the working of this complex molecular machinery is still not completely resolved. A computational model of the entire process of protein synthesis would be a powerful tool to help us understand the process and to raise new questions that drive new experiments. Here I will present a comprehensive model of eukariotic protein synthesis, including initiation, elongation and termination based on chemical kinetics. The calibration of this model was possible through comprehensive parameter estimation based on a large experimental data set and intensive use of high-throughput computing. Simulations based on this model suggest new hypotheses about mechanistic details but also reveal where the model is incorrect and suggest improvements that will result in a closing of the loop between model and experiment.
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Seminar |
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Date： |
December 13, 2012(Thu.) 17:00～18:30 |
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Place： |
Faculty
of Science Bldg.3, 4F, room 412 |
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Host： |
Shinya
Kuroda(skuroda AT bi.s.u-tokyo.ac.jp) |
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