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Global COE Special Seminar
Molecular mechanisms of hippocampal long-term potentiation

Yasunori HAYASHI, M.D., Ph.D.
RIKEN-MIT Neuroscience Research Center
The Picower Institute for Learning and Memory
Department of Brain and Congnitive Sciences
   In hippocampus, a transient burst of input activity leads to a long-term potentiation (LTP)
of subsequent synaptic transmission. This phenomenon has been considered as a cellular
counterpart and attracted interest of many neuroscientists. In an attempt to elucidate
the molecular mechanism, I have been using a combined approach of molecular biology,
imaging and electrophysiology, which allows us to specifically "look", "mimic" and "block"
the process underlying LTP.
   In this talk, I will summarize my results how synapse reaches the potentiated level and
what is the question now.
Global COE Special Seminar
Date: December 17, 2008(Wed) 18:00~19:30
Place: Faculty of Science Bldg.3, 4F, room 412
Host: Shinya Kuroda(skuroda AT bi.s.u-tokyo.ac.jp)
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