//genesis // kkit Version 10 flat dumpfile // This is a script file for GENESIS/kinetikit (kkit ver. 10). // Information of GENESIS/Kinetikit is available on the following address. // http://www.ncbs.res.in/~bhalla/GENESIS/ // http://www.genesis-sim.org/GENESIS/ // Saved on Wed Feb 16 20:47:32 2005 include kkit {argv 1} FASTDT = 0.002 SIMDT = 0.01 CONTROLDT = 1 PLOTDT = 10 MAXTIME = 3700 TRANSIENT_TIME = 10 VARIABLE_DT_FLAG = 1 DEFAULT_VOL = 1.6667e-21 VERSION = 10.0 setfield /file/modpath value /home/user1/work kparms //genesis initdump -version 3 -ignoreorphans 1 simobjdump table input output alloced step_mode stepsize x y z simobjdump xtree path script namemode sizescale simobjdump xcoredraw xmin xmax ymin ymax simobjdump xtext editable simobjdump xgraph xmin xmax ymin ymax overlay simobjdump xplot pixflags script fg ysquish do_slope wy simobjdump group xtree_fg_req xtree_textfg_req plotfield expanded movealone \ link savename file version md5sum mod_save_flag x y z simobjdump kpool CoTotal CoInit Co n nInit nTotal nMin vol slave_enable notes \ xtree_fg_req xtree_textfg_req x y z simobjdump kreac kf kb notes xtree_fg_req xtree_textfg_req x y z simobjdump kenz CoComplexInit CoComplex nComplexInit nComplex vol k1 k2 k3 \ keepconc usecomplex notes xtree_fg_req xtree_textfg_req link x y z simobjdump stim level1 width1 delay1 level2 width2 delay2 baselevel trig_time \ trig_mode notes xtree_fg_req xtree_textfg_req is_running x y z simobjdump xtab input output alloced step_mode stepsize notes editfunc \ xtree_fg_req xtree_textfg_req baselevel last_x last_y is_running x y z simobjdump kchan perm gmax Vm is_active use_nernst notes xtree_fg_req \ xtree_textfg_req x y z simobjdump transport input output alloced step_mode stepsize dt delay clock \ kf xtree_fg_req xtree_textfg_req x y z simobjdump proto x y z simobjdump linkinfo xtree_fg_req xtree_textfg_req uplink downlink x y z simobjdump uplink xtree_fg_req xtree_textfg_req x y z simobjdump downlink xtree_fg_req xtree_textfg_req x y z simobjdump mirror notes xtree_fg_req x y z simundump kpool /kinetics/Ras-GDP 0 0.2 0.1 0.1 6786 6786 13572 0 67860 0 "" \ blue black -1332 -594 0 simundump kpool /kinetics/Rap1_GAP 0 1 0.012 0.012 814.32 814.32 67860 0 \ 67860 0 "" blue black -1306 -593 0 simundump kenz /kinetics/Rap1_GAP/kenz[1] 0 0 0 0 0 67860 0.0029768 200 2 0 0 \ "" red blue "" -1306 -592 0 simundump kenz /kinetics/Rap1_GAP/kenz2 0 0 0 0 0 67860 0.0029768 200 2 0 0 \ "" red blue "" -1306 -594 0 simundump kreac /kinetics/Ras_GTPase 0 0.00016666 0 "" white black -1324 -595 \ 0 simundump group /kinetics/Sos_Grb2 0 6 black x 0 1 "" Sos_Grb2 \ /home/user1/work/Sos_Grb2_0.g 0 0 0 -1316 -550 0 simundump kpool /kinetics/Sos_Grb2/Grb2 1 8.842 0.94001 0.94001 63787 63787 \ 6e+05 0 67858 0 "" orange 6 -1327 -553 0 simundump kpool /kinetics/Sos_Grb2/Sos 1 0.8842 0.04 0.039999 2714.2 2714.3 \ 60000 0 67858 0 "" red 6 -1335 -553 0 simundump kpool /kinetics/Sos_Grb2/Sos* 1 0.0070001 0 0 0 0 475.01 0 67858 0 \ "" red 6 -1318 -553 0 simundump kreac /kinetics/Sos_Grb2/dephosph_Sos 1 0.002 0 "" white 6 -1331 \ -548 0 simundump kreac /kinetics/Sos_Grb2/Grb2_bind_Sos* 1 4.421e-07 0.0168 "" white \ 6 -1321 -556 0 simundump kreac /kinetics/Sos_Grb2/Grb2_bind_Sos 1 4.421e-07 0.0168 "" white \ 6 -1332 -556 0 simundump group /kinetics/Sos_Grb2/probe 0 yellow 6 x 0 1 "" probe \ /home/user1/work/probe_0.g 0 0 0 -1313 -548 0 simundump kpool /kinetics/Sos_Grb2/probe/pSos_total 1 0 0 0 0 0 0 0 67858 0 \ "" 0 yellow -1307 -555 0 simundump kpool /kinetics/Sos_Grb2/probe/effect_Sos_total 1 0 0 0 0 0 0 0 \ 67858 0 "" brown yellow -1307 -549 2 simundump kpool /kinetics/Sos_Grb2/Sos.Grb2 1 0.06 0.06 0.060001 4071.6 \ 4071.5 4071.5 0 67858 0 "" orange 6 -1335 -559 0 simundump kpool /kinetics/Sos_Grb2/pSos.Grb2 1 0.020001 0 0 0 0 1357.2 0 \ 67858 0 "" orange 6 -1318 -559 0 simundump group /kinetics/SHC 0 48 black x 0 1 "" SHC \ /home/user1/work/SHC_0.g 0 0 0 -1310 -567 0 simundump kreac /kinetics/SHC/dephosph_Shc 1 0.005 0 "" white 48 -1311 -574 0 simundump group /kinetics/SHC/probe 0 26 48 x 0 1 "" probe \ /home/user1/work/probe_0.g 0 0 0 -1310 -565 0 simundump kpool /kinetics/SHC/probe/pShc_total 1 0 0 0 0 0 0 0 67858 0 "" \ orange 26 -1322 -583 0 simundump kpool /kinetics/SHC/probe/non-pShc_total 1 1 0 1 67858 0 67858 0 \ 67858 0 "" orange 26 -1330 -563 0 simundump kpool /kinetics/SHC/probe/Shc_total 1 0 0 1 67858 0 67858 0 67858 0 \ "" orange 26 -1324 -568 0 simundump kpool /kinetics/SHC/Shc 1 8.842 1 1 67858 67858 6e+05 0 67858 0 "" \ orange 48 -1313 -572 0 simundump kpool /kinetics/SHC/pShc 1 1.4737e-05 0 0 0 0 1 0 67858 0 "" orange \ 48 -1313 -576 0 simundump kreac /kinetics/SHC/pShc_bind_Sos.Grb2 1 0.00014737 0.2 "" white 48 \ -1315 -566 0 simundump kpool /kinetics/SHC/pShc.Sos.Grb2 1 1.4737e-05 0 0 0 0 1 0 67858 0 \ "" brown 48 -1313 -579 0 simundump kreac /kinetics/dephosph_Shc[1] 1 0.005 0 "" white yellow -1311 \ -577 0 simundump kpool /kinetics/Ras_GAP* 0 0.02 0.0018 0.0018 122.15 122.15 1357.2 \ 0 67860 0 "" blue black -1322 -598 0 simundump kenz /kinetics/Ras_GAP*/kenz 0 0 0 0 0 67860 0.00073685 40 10 0 0 \ "" red blue "" -1324 -597 0 simundump kenz /kinetics/Ras_GAP*/kenz2 0 0 0 0 0 67860 0.00073685 40 10 0 0 \ "" red blue "" -1320 -597 0 simundump kenz /kinetics/Ras_GAP*/kenz3 0 0 0 0 0 67860 0.00073685 40 10 0 0 \ "" red blue "" -1329 -597 0 simundump kpool /kinetics/Ras_GAP 0 256 0.1 0.1 6786 6786 1.7372e+07 0 67860 \ 0 "" blue black -1344 -592 0 simundump group /kinetics/NGF_ramp 0 yellow black x 0 0 "" yellow \ /home/user1/work/yellow_0.g 0 0 0 -1258 -532 0 simundump kpool /kinetics/NGF_ramp/GATE 1 1.4737e-05 0 1.5 1.0179e+05 0 1 0 \ 67858 2 "" 47 yellow -1251 -535 2 simundump kreac /kinetics/NGF_ramp/kreac[10] 0 1.3634e-09 0 "" white yellow \ -1248 -538 0 simundump stim /kinetics/NGF_ramp/multiplier 0 0 10000 7300 0 0 0 1.5 -1 0 "" \ white yellow 3 -1259 -536 0 simundump stim /kinetics/NGF_ramp/stim_NGF_3ng 0 0.000115 10000 100 0 0 0 0 \ -1 0 "" white yellow 3 -1259 -539 0 simundump kpool /kinetics/NGF_ramp/NGF_pulse 1 1.4737e-05 0 0 0 0 1 0 67858 2 \ "" red yellow -1253 -537 0 simundump kpool /kinetics/NGF_ramp/NGF[2] 1 1.4737e-05 0 0 0 0 1 0 67858 0 "" \ red yellow -1243 -537 0 simundump kpool /kinetics/ubiquitine 0 5 5 5 3.393e+05 3.393e+05 3.393e+05 0 \ 67860 4 "" blue yellow -1383 -579 0 simundump group /kinetics/U0126_group 0 yellow black x 0 0 "" U0126_group \ /home/user1/work/U0126_group_0.g 0 0 0 -1359 -617 0 simundump kpool /kinetics/U0126_group/U0126 0 50 0 0 0 0 3.3929e+06 0 67858 0 \ "" white yellow -1356 -621 0 simundump kpool /kinetics/U0126_group/U0126.MEK 0 0 0 0 0 0 0 0 67858 0 "" \ white yellow -1347 -620 0 simundump kpool /kinetics/U0126_group/U0126.MEK_P 0 0 0 0 0 0 0 0 67858 0 "" \ white yellow -1338 -620 0 simundump kpool /kinetics/U0126_group/U0126.MEK_PP 0 0 0 0 0 0 0 0 67858 0 "" \ white yellow -1331 -620 0 simundump kpool /kinetics/U0126_group/U0126.MEK.Erk2 0 0.24999 0 0 0 0 16964 \ 0 67858 0 "" 31 yellow -1351 -631 0 simundump kpool /kinetics/U0126_group/U0126.pMEK.Erk2 0 0.24999 0 0 0 0 16964 \ 0 67858 0 "" 31 yellow -1341 -631 0 simundump kpool /kinetics/U0126_group/U0126.ppMEK.Erk2 0 0.24999 0 0 0 0 \ 16964 0 67858 0 "" 31 yellow -1332 -631 0 simundump kreac /kinetics/U0126_group/kreac[1] 0 0.00024026 0.6 "" white \ yellow -1346 -626 0 simundump kreac /kinetics/U0126_group/U0126_bind_MEK 0 7.3683e-06 0.1 "" \ white yellow -1349 -624 0 simundump kreac /kinetics/U0126_group/U0126_bind_MEK_P 0 7.3683e-06 0.1 "" \ white yellow -1343 -624 0 simundump kreac /kinetics/U0126_group/kreac[4] 0 0.00024026 0.6 "" white \ yellow -1339 -626 0 simundump kreac /kinetics/U0126_group/kreac[9] 0 0.00024026 0.6 "" white \ yellow -1334 -626 0 simundump kreac /kinetics/U0126_group/U0126_bind_MEK_PP 0 7.3683e-06 0.1 "" \ white yellow -1335 -624 0 simundump group /kinetics/TrkA 0 10 black x 0 1 "" TrkA \ /home/user1/work/TrkA_0.g 0 0 0 -1283 -552 0 simundump kpool /kinetics/TrkA/endo_TrkA 0 0 0 0 0 0 0 0 67858 0 "" yellow 10 \ -1252 -590 0 simundump kreac /kinetics/TrkA/GTPase 0 0.00011666 0 "" white 10 -1278 -592 0 simundump kreac /kinetics/TrkA/autophosphorylation 0 1 0 "" white 10 -1277 \ -554 0 simundump kpool /kinetics/TrkA/L.TrkA 0 0 0 0 0 0 0 0 67858 0 "" blue 10 \ -1272 -552 0 simundump kpool /kinetics/TrkA/NGF 0 0 0 0 0 0 2.4209e-322 0 67858 0 "" blue \ 10 -1270 -549 0 simundump kreac /kinetics/TrkA/degradation 0 0.003 0 "" white 10 -1223 -589 0 simundump kpool /kinetics/TrkA/Glycocyl_transferase 0 0.06877 0.0001 0.0001 \ 6.7858 6.7858 4666.6 0 67858 6 "" blue 10 -1246 -549 0 simundump kenz /kinetics/TrkA/Glycocyl_transferase/glycosylation 0 0 0 0 0 \ 67858 0.01 0.04 0.01 0 0 "" red blue "" -1246 -548 0 simundump kpool /kinetics/TrkA/Buffer 0 0 0 0 0 0 0 0 67858 4 "" blue 10 \ -1223 -580 0 simundump kreac /kinetics/TrkA/degradation2 0 0.00027777 0 "" white 10 -1226 \ -553 0 simundump stim /kinetics/TrkA/NGF0.1 0 3.8e-06 10000 100 0 0 0 0 -1 0 "" 56 \ 10 3 -1269 -543 0 simundump kpool /kinetics/TrkA/sum_non_phospho_TrkA 0 0.061894 0 0.061894 \ 4200 0 4200 0 67858 0 "" blue 10 -1229 -555 0 simundump kreac /kinetics/TrkA/TrkA_synthesis 0 0.00083333 0 "" white 10 \ -1254 -546 0 simundump kpool /kinetics/TrkA/pro-TrkA 0 0.1 0.020631 0.020631 1400 1400 \ 6785.8 0 67858 6 "" blue 10 -1242 -546 0 simundump kreac /kinetics/TrkA/dephospho_FRS2 0 0.005 0 "" white 10 -1302 \ -574 0 simundump kpool /kinetics/TrkA/L.dpTrkA 0 0 0 0 0 0 0 0 67858 0 "" blue 10 \ -1272 -556 0 simundump kpool /kinetics/TrkA/p75 0 0.64839 0.58945 0.58945 40000 40000 \ 44000 0 67860 0 "" blue 10 -1264 -548 0 simundump stim /kinetics/TrkA/stim_NGF_100ng 0 0.0038 10000 100 0 0 0 0 -1 0 \ "" white 10 3 -1282 -548 0 simundump stim /kinetics/TrkA/stim_NGF_10ng 0 0.00038 10000 100 0 0 0 0 -1 0 \ "" white 10 3 -1277 -546 0 simundump stim /kinetics/TrkA/stim_NGF_1ng 0 3.8e-05 10000 100 0 0 0 0 -1 0 \ "" white 10 3 -1272 -544 0 simundump stim /kinetics/TrkA/stim_NGF_1.5ng 0 5.7e-05 10000 100 0 0 0 0 -1 0 \ "" white 10 3 -1275 -545 0 simundump kpool /kinetics/TrkA/TrkA_total 0 0 0 0.061894 4200 0 4200 0 67858 \ 0 "" green 10 -1218 -570 0 simundump kpool /kinetics/TrkA/pTrkA_total 0 0 0 0 0 0 0 0 67858 0 "" 43 10 \ -1223 -575 0 simundump kpool /kinetics/TrkA/Crk.C3G 0 1 0 0.0050001 339.3 0 67858 0 67858 \ 0 "" blue 10 -1298 -556 0 simundump kpool /kinetics/TrkA/Crk 0 1 1 0.99501 67520 67858 67858 0 67858 0 \ "" blue 10 -1294 -550 0 simundump kpool /kinetics/TrkA/C3G 0 1 0.5 0.49502 33591 33929 67858 0 67858 \ 0 "" blue 10 -1303 -550 0 simundump kreac /kinetics/TrkA/Crk_bind_C3G 0 1.4737e-05 0.002 "" white 10 \ -1298 -553 0 simundump stim /kinetics/TrkA/stim_NGF_50ng 0 0.0019 10000 100 0 0 0 0 -1 0 \ "" white 10 3 -1279 -547 0 simundump stim /kinetics/TrkA/stim_NGF_5ng 0 0.00019 10000 100 0 0 0 0 -1 0 \ "" white 10 3 -1279 -543 0 simundump stim /kinetics/TrkA/stim_NGF_0.5ng 0 1.9e-05 10000 100 0 0 0 0 -1 0 \ "" white 10 3 -1276 -541 0 simundump kpool /kinetics/TrkA/Rap1GTP 0 0 0 0 0 0 0 0 67858 0 "" red 10 \ -1286 -595 0 simundump kpool /kinetics/TrkA/Rap1.GTP_total 0 0 0 0 0 0 0 0 67860 0 "" 5 10 \ -1285 -601 0 simundump group /kinetics/TrkA/pTrkA_g 0 magenta 10 x 0 0 "" pTrkA_g \ /home/user1/work/pTrkA_g_0.g 0 0 0 -1261 -560 0 simundump kpool /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 0 0 0 0 0 0 0 0 67858 0 "" \ pink magenta -1249 -559 0 simundump kreac /kinetics/TrkA/pTrkA_g/FRS2_Tyr_phosphory 0 2 0 "" white \ magenta -1246 -561 0 simundump kpool /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 0 0 0 0 0 0 0 0 67858 0 "" \ pink magenta -1248 -564 0 simundump group /kinetics/TrkA/pTrkA_g/probe 0 26 magenta x 0 0 "" 356 \ /home/user1/work/356_0.g 0 0 0 -1258 -558 0 simundump kpool /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr 0 0 0 0 0 0 0 0 \ 67858 0 "" magenta 26 -1262 -557 0 simundump kenz /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr/TrkA_act_Dok 0 0 0 0 \ 0 67858 1.4737e-05 0.08 0.02 0 1 "" red magenta "" -1366 -596 0 simundump kpool /kinetics/TrkA/pTrkA_g/probe/pShc_total 0 0 0 0 0 0 0 0 67858 \ 0 "" orange 26 -1288 -571 0 simundump kpool /kinetics/TrkA/pTrkA_g/probe/non-pShc_total 0 0 0 0 0 0 0 0 \ 67858 0 "" orange 26 -1287 -565 0 simundump kpool /kinetics/TrkA/pTrkA_g/probe/TrkA_surface 0 0.061894 0 \ 0.061894 4200 0 4200 0 67858 0 "" purple 26 -1252 -555 0 simundump kpool /kinetics/TrkA/pTrkA_g/probe/Sos.pTrkA_total 1 0 0 0 0 0 0 0 \ 67858 0 "" brown 26 -1281 -556 0 simundump kpool /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2.Crk.C3G_membr 0 0 0 0 0 0 \ 0 0 67858 0 "" pink magenta -1257 -563 0 simundump kpool /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 0 0 0 0 0 0 0 0 \ 67858 0 "" "medium purple" magenta -1278 -563 0 simundump kenz /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2/TrkA.Shc.Grb2.Sos_act 0 \ 0 0 0 0 67858 0.0073683 8 2 0 1 "" red "medium purple" "" -1315 -587 0 simundump kpool /kinetics/TrkA/pTrkA_g/pTrkA.Shc 0 0 0 0 0 0 0 0 67858 0 "" \ "medium purple" magenta -1272 -560 0 simundump kpool /kinetics/TrkA/pTrkA_g/pTrkA.pShc 0 0 0 0 0 0 0 0 67858 0 "" \ "medium purple" magenta -1284 -561 0 simundump kreac /kinetics/TrkA/pTrkA_g/Shc_Tyr_phosphory 0 0.1 0 "" white \ magenta -1278 -558 0 simundump kreac /kinetics/TrkA/pTrkA_g/FRS2_bind_pTrkA 0 7.3683e-05 0.1 "" \ white magenta -1295 -563 0 simundump kreac /kinetics/TrkA/pTrkA_g/Crk_bind_pFRS2 0 1.4737e-05 0.2 "" \ white magenta -1295 -560 0 simundump kreac /kinetics/TrkA/pTrkA_g/pFRS2_bind_pTrkA 0 7.3683e-05 0.1 "" \ white magenta -1295 -564 0 simundump kreac /kinetics/TrkA/pTrkA_g/Shc_bind_pTrkA 0 0.00014737 0.2 "" \ white magenta -1295 -568 0 simundump kreac /kinetics/TrkA/pTrkA_g/pShc_bind_pTrkA 0 0.00014737 0.2 "" \ white magenta -1295 -569 0 simundump kreac /kinetics/TrkA/pTrkA_g/pShc_bind_Sos.Grb2[3] 1 0.00014737 0.2 \ "" white magenta -1295 -558 0 simundump kreac /kinetics/TrkA/pTrkA_g/pShc.Grb2_bind_pTrkA[1] 0 0.00014737 \ 0.2 "" white magenta -1295 -570 0 simundump kreac /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph 0 0.0022 0 "" white \ magenta -1238 -557 0 simundump kreac /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[1] 0 0.0022 0 "" \ white magenta -1238 -558 0 simundump kreac /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[2] 0 0.0022 0 "" \ white magenta -1238 -559 0 simundump kreac /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[3] 0 0.0022 0 "" \ white magenta -1238 -560 0 simundump kreac /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[4] 0 0.0022 0 "" \ white magenta -1238 -561 0 simundump kreac /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[5] 0 0.0022 0 "" \ white magenta -1238 -562 0 simundump kreac /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[6] 0 0.0022 0 "" \ white magenta -1238 -563 0 simundump group /kinetics/TrkA/pTrkA_endo_g 0 brown 10 x 0 0 "" pTrkA_endo_g \ /home/user1/work/pTrkA_endo_g_0.g 0 0 0 -1274 -570 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/Internalization[1] 0 0.00063 0 "" \ white brown -1282 -568 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/Internalization[4] 0 0.00063 0 "" \ white brown -1265 -565 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/Internalization[2] 0 0.00063 0 "" \ white brown -1261 -568 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/Internalization[5] 0 0.00063 0 "" \ white brown -1252 -567 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/Internalization 0 0.00063 0 "" \ white brown -1242 -568 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/Internalization[3] 0 0.00063 0 "" \ white brown -1278 -567 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/Shc_Tyr_phosphory[1] 0 0.1 0 "" \ white brown -1278 -559 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/FRS2_Tyr_phosphory[1] 0 2 0 "" \ white brown -1246 -562 0 simundump kpool /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo 0 0 0 0 0 0 0 0 \ 67858 0 "" blue brown -1265 -571 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/Crk_bind_pFRS2[1] 0 1.4737e-05 \ 0.2 "" white brown -1295 -561 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/pFRS2_bind_pTrkA[1] 0 7.3683e-05 \ 0.1 "" white brown -1295 -566 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/FRS2_bind_pTrkA[1] 0 7.3683e-05 \ 0.1 "" white brown -1295 -565 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/pShc_bind_pTrkA 0 0.00014737 0.2 \ "" white brown -1295 -573 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/Shc_bind_pTrkA 0 0.00014737 0.2 \ "" white brown -1295 -572 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/pShc_bind_Sos.Grb2 1 0.00014737 \ 0.2 "" white brown -1295 -559 0 simundump kpool /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo 0 0 0 0 0 0 0 0 \ 67858 0 "" "medium purple" brown -1282 -573 0 simundump kpool /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo 0 0 0 0 0 0 0 0 \ 67858 0 "" "medium purple" brown -1272 -575 0 simundump kpool /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo 0 0 0 0 \ 0 0 0 0 67858 0 "" "medium purple" brown -1280 -578 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[2] 0 0.00042 0 \ "" white brown -1288 -581 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3 0 0.00042 0 "" \ white brown -1278 -582 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[3] 0 0.00042 0 \ "" white brown -1257 -581 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[1] 0 0.00042 0 \ "" white brown -1240 -581 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[4] 0 0.00042 0 \ "" white brown -1248 -580 0 simundump kpool /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo 0 0 0 0 \ 0 0 0 0 67858 0 "" pink brown -1253 -577 0 simundump kenz /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo/TrkA-C3G_act 0 \ 0 0 0 0 67857 7.0736e-05 0.024 0.024 0 1 "" red pink "" -1275 -589 0 simundump kpool /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo 0 0 0 0 0 0 0 0 \ 67858 0 "" pink brown -1248 -573 0 simundump kpool /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo 0 0 0 0 0 0 0 0 \ 67858 0 "" pink brown -1238 -575 0 simundump kreac /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[5] 0 0.00042 0 \ "" white brown -1264 -579 0 simundump kreac 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0 0 1357.2 0 0 \ 67860 0 "" 47 55 -1328 -627 0 simundump kpool /kinetics/MAPK/probe/Rap1-GTP_total 0 0.01 0.01 0 0 678.6 0 0 \ 67860 0 "" 56 55 -1300 -602 0 simundump kpool /kinetics/MAPK/probe/Ras_B-Raf_total 0 0 0 0 0 0 0 0 67860 0 \ "" 8 55 -1315 -605 0 simundump kpool /kinetics/MAPK/probe/Ras-GTP_total 0 0 0 0 0 0 0 0 67860 0 "" \ 62 55 -1332 -603 0 simundump kpool /kinetics/MAPK/probe/pMEK_total 0 0 0 0 0 0 0 0 67858 0 "" 31 \ 55 -1341 -608 0 simundump kpool /kinetics/MAPK/probe/non-pMEK_total 0 0.68001 0 0.68001 46144 \ 0 46144 0 67858 0 "" 31 55 -1347 -610 0 simundump kpool /kinetics/MAPK/probe/non-pMEK_in-complex 0 0 0 0 0 0 0 0 \ 67858 0 "" 24 55 -1323 -621 0 simundump kpool /kinetics/MAPK/probe/pMEK_in-complex 0 0 0 0 0 0 0 0 67858 0 \ "" 24 55 -1319 -622 0 simundump kpool /kinetics/MAPK/probe/ppMEK_in-complex 0 0 0 0 0 0 0 0 67858 0 \ "" 24 55 -1320 -627 0 simundump kpool /kinetics/MAPK/probe/ppMEK_total 0 0 0 0 0 0 0 0 67858 0 "" \ 31 55 -1335 -606 0 simundump kpool 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"" red blue "" -1346 -634 0 simundump kenz /kinetics/MAPK/PP2A/dephosThr[2] 0 0 0 0 0 67860 1.4118e-05 12 \ 3 0 0 "" red blue "" -1335 -634 0 simundump kpool /kinetics/MAPK/B-Raf 0 0.2 0.2 0.2 13572 13572 13572 0 67860 \ 0 "" blue 21 -1311 -599 0 simundump kpool /kinetics/MAPK/Ras-GTP 0 0.008 0 0 0 0 542.88 0 67860 0 "" 62 \ 21 -1316 -594 0 simundump kpool /kinetics/MAPK/C-Raf 0 0.5 0.5 0.5 33930 33930 33930 0 67860 \ 0 "" blue 21 -1331 -600 0 simundump kpool /kinetics/MAPK/Rap1_B-Raf 0 0 0 0 0 0 0 0 67860 0 "" 5 21 \ -1299 -606 0 simundump kenz /kinetics/MAPK/Rap1_B-Raf/ser 0 0 0 0 0 67860 0.00013815 1.2 \ 0.3 0 0 "" red 5 "" -1314 -609 0 simundump kenz /kinetics/MAPK/Rap1_B-Raf/thr 0 0 0 0 0 67860 0.00013815 1.2 \ 0.3 0 0 "" red 5 "" -1303 -609 0 simundump kenz /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser 0 0 0 0 0 67860 \ 0.00013815 1.2 0.3 0 0 "" red 5 "" -1343 -615 0 simundump kenz /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr 0 0 0 0 0 67860 \ 0.00013815 1.2 0.3 0 0 "" red 5 "" -1333 -615 0 simundump kenz /kinetics/MAPK/Rap1_B-Raf/ser[1] 0 0 0 0 0 67860 0.00013815 \ 1.2 0.3 0 0 "" red 5 "" -1314 -613 0 simundump kenz /kinetics/MAPK/Rap1_B-Raf/thr[1] 0 0 0 0 0 67860 0.00013815 \ 1.2 0.3 0 0 "" red 5 "" -1303 -613 0 simundump kenz /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser[1] 0 0 0 0 0 67860 \ 0.00013815 1.2 0.3 0 0 "" red 5 "" -1346 -628 0 simundump kenz /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr[1] 0 0 0 0 0 67860 \ 0.00013815 1.2 0.3 0 0 "" red 5 "" -1336 -628 0 simundump kpool /kinetics/MAPK/Ras_B-Raf 0 0 0 0 0 0 0 0 67860 0 "" 8 21 \ -1309 -606 0 simundump kenz /kinetics/MAPK/Ras_B-Raf/ser 0 0 0 0 0 67860 9.2101e-05 0.8 \ 0.2 0 0 "" red 8 "" -1316 -608 0 simundump kenz /kinetics/MAPK/Ras_B-Raf/thr 0 0 0 0 0 67860 9.2101e-05 0.8 \ 0.2 0 0 "" red 8 "" -1305 -608 0 simundump kenz /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser 0 0 0 0 0 67860 \ 9.2101e-05 0.8 0.2 0 1 "" red 8 "" -1343 -616 0 simundump kenz /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr 0 0 0 0 0 67860 \ 9.2101e-05 0.8 0.2 0 0 "" red 8 "" -1333 -616 0 simundump kenz /kinetics/MAPK/Ras_B-Raf/ser[1] 0 0 0 0 0 67860 9.2101e-05 0.8 \ 0.2 0 0 "" red 8 "" -1316 -612 0 simundump kenz /kinetics/MAPK/Ras_B-Raf/thr[1] 0 0 0 0 0 67860 9.2101e-05 0.8 \ 0.2 0 0 "" red 8 "" -1305 -612 0 simundump kenz /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser[1] 0 0 0 0 0 67860 \ 9.2101e-05 0.8 0.2 0 0 "" red 8 "" -1346 -629 0 simundump kenz /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr[1] 0 0 0 0 0 67860 \ 9.2101e-05 0.8 0.2 0 0 "" red 8 "" -1336 -629 0 simundump kpool /kinetics/MAPK/Ras_C-Raf 0 0 0 0 0 0 0 0 67860 0 "" blue 21 \ -1321 -606 0 simundump kenz /kinetics/MAPK/Ras_C-Raf/ser 0 0 0 0 0 67860 0.00023025 2 0.5 \ 0 0 "" red blue "" -1318 -609 0 simundump kenz /kinetics/MAPK/Ras_C-Raf/thr 0 0 0 0 0 67860 0.00023025 2 0.5 \ 0 0 "" red blue "" -1307 -609 0 simundump kenz /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr 0 0 0 0 0 67860 \ 0.00023025 2 0.5 0 0 "" red blue "" -1333 -617 0 simundump kenz /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser 0 0 0 0 0 67860 \ 0.00023025 2 0.5 0 0 "" red blue "" -1343 -617 0 simundump kenz /kinetics/MAPK/Ras_C-Raf/thr[1] 0 0 0 0 0 67860 0.00023025 2 \ 0.5 0 0 "" red blue "" -1306 -613 0 simundump kenz /kinetics/MAPK/Ras_C-Raf/ser[1] 0 0 0 0 0 67860 0.00023025 2 \ 0.5 0 0 "" red blue "" -1318 -613 0 simundump kenz /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser[1] 0 0 0 0 0 67860 \ 0.00023025 2 0.5 0 0 "" red blue "" -1346 -630 0 simundump kenz /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr[1] 0 0 0 0 0 67860 \ 0.00023025 2 0.5 0 0 "" red blue "" -1336 -630 0 simundump kreac /kinetics/MAPK/Ras_bind_B-Raf 0 0.00088417 0.5 "" white 21 \ -1311 -602 0 simundump kreac /kinetics/MAPK/Rap1_bind_B-Raf 0 0.00088417 0.5 "" white 21 \ -1299 -597 0 simundump kreac /kinetics/MAPK/Ras_bind_C-Raf 0 0.00088417 0.5 "" white 21 \ -1320 -602 0 simundump group /kinetics/Dok-RasGAP 0 yellow black x 0 0 "" Dok-RasGAP \ /home/user1/work/Dok-RasGAP_0.g 0 0 0 -1358 -599 0 simundump kreac /kinetics/Dok-RasGAP/dephospho_ppDok2 0 0.002 1e-05 "" white \ yellow -1371 -602 0 simundump kpool /kinetics/Dok-RasGAP/Dok2 1 0.29999 0.29999 0.29999 20357 \ 20357 20357 0 67858 0 "" "royal blue" yellow -1377 -599 0 simundump group /kinetics/Dok-RasGAP/probe 0 yellow yellow x 0 0 "" probe \ /home/user1/work/probe_0.g 0 0 0 -1353 -597 0 simundump kreac /kinetics/Dok-RasGAP/ppDok2_bind_RasGAP 0 1.7683e-06 0.01 "" \ white yellow -1342 -597 0 simundump kpool /kinetics/Dok-RasGAP/pDok2 1 0.1 0.0015 0.0015 101.79 101.79 \ 6785.8 0 67858 0 "" "royal blue" yellow -1364 -599 0 simundump kpool /kinetics/ppDoc2_total 1 0.94001 0.94001 0.0033001 223.94 \ 63787 223.94 0 67858 0 "" orange yellow -1355 -602 0 simundump group /kinetics/FRS2_g 0 yellow black x 0 1 "" 356 \ /home/user1/work/356_0.g 0 0 0 -1301 -567 0 simundump kpool /kinetics/FRS2_g/FRS2 0 1 1 1 67858 67858 67858 0 67858 0 "" \ blue yellow -1304 -572 0 simundump kpool /kinetics/FRS2_g/pFRS2 0 0 0 0 0 0 0 0 67858 0 "" blue yellow \ -1304 -576 0 simundump group /kinetics/FRS2_g/probe 0 26 yellow x 0 1 "" probe \ /home/user1/work/probe_0.g 0 0 0 -1301 -565 0 simundump kpool /kinetics/FRS2_g/probe/FRS2_total 0 1 0 1 67858 0 67858 0 \ 67858 0 "" blue 26 -1306 -569 0 simundump kpool /kinetics/FRS2_g/probe/pFRS2_total 0 0 0 0 0 0 0 0 67858 0 "" \ blue 26 -1303 -581 0 simundump group /kinetics/EGFR_g 1 red black x 0 1 "" "Version # 0" \ "/home/user1/work/Version # 0_0.g" 0 0 0 -1380 -558 0 simundump kpool /kinetics/EGFR_g/EGFR 1 2.6526 0.29999 0.29999 20357 20357 \ 1.8e+05 0 67858 0 "" red red -1359 -548 0 simundump kreac /kinetics/EGFR_g/activate_EGFR 1 3.3648e-05 0.0029666 "" \ white red -1349 -550 0 simundump kpool /kinetics/EGFR_g/EGF 1 0.0016936 0 0 0 0 114.92 0 67858 2 "" \ red red -1343 -548 0 simundump kpool /kinetics/EGFR_g/L.EGFR 1 1.4737e-05 0 0 0 0 1 0 67858 0 "" \ red red -1353 -553 0 simundump kreac /kinetics/EGFR_g/dimerize_EGFR 1 0.00014737 0.02 "" white red \ -1365 -554 0 simundump kreac /kinetics/EGFR_g/Tyr_phosphory 0 4 0.001 "" white red -1365 \ -557 0 simundump kpool /kinetics/EGFR_g/L.EGFR_dimer 0 0 0 0 0 0 0 0 67860 0 "" blue \ red -1354 -556 0 simundump group /kinetics/EGFR_g/probe 0 26 red x 0 1 "" probe \ /home/user1/work/probe_0.g 0 0 0 -1387 -558 0 simundump kpool /kinetics/EGFR_g/probe/EGFR_ubiq_total 0 0 0 0 0 0 0 0 67858 \ 0 "" 21 26 -1367 -588 0 simundump kpool /kinetics/EGFR_g/probe/non-ubiqEGFR*_total 0 0 0 0 0 0 0 0 \ 67860 0 "" 26 26 -1357 -574 0 simundump kenz /kinetics/EGFR_g/probe/non-ubiqEGFR*_total/EGFR_act_Dok2 0 0 0 \ 0 0 67860 0.00014736 0.8 0.2 0 1 "" red 26 "" -1378 -596 0 simundump kpool /kinetics/EGFR_g/probe/EGFR*_total 0 0 0 0 0 0 0 0 67860 0 "" \ 26 26 -1349 -589 0 simundump kpool /kinetics/EGFR_g/probe/pEGFR.pFRS2_total 0 0 0 0 0 0 0 0 \ 67858 0 "" turquoise 26 -1332 -567 0 simundump kpool /kinetics/EGFR_g/probe/effective_C3G_total 0 0 0 0 0 0 0 0 \ 67858 0 "" turquoise 26 -1328 -571 0 simundump kpool /kinetics/EGFR_g/probe/pShc.pEGFR_total 1 0 0 0 0 0 0 0 67858 \ 0 "" brown 26 -1372 -563 0 simundump 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0.0073683 8 2 0 1 "" red brown "" -1336 -591 0 simundump kpool /kinetics/EGFR_g/pEGFR_g/L.dpEGFR 1 1.4737e-05 0 0 0 0 1 0 \ 67858 0 "" red magenta -1354 -559 0 simundump kreac /kinetics/EGFR_g/pEGFR_g/FRS2_Tyr_phosphory 0 1 0 "" white \ magenta -1350 -562 0 simundump kreac /kinetics/EGFR_g/pEGFR_g/Shc_phosphory[1] 0 1 0 "" white \ magenta -1376 -561 0 simundump kpool /kinetics/EGFR_g/pEGFR_g/FRS2.pEGFR 0 0.00041908 0 0 0 0 \ 28.438 0 67858 0 "" turquoise magenta -1343 -561 0 simundump kpool /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR 0 0.00041908 0 0 0 0 \ 28.438 0 67858 0 "" turquoise magenta -1343 -564 0 simundump kpool /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR 0 0 0 0 0 0 0 0 \ 67858 0 "" turquoise magenta -1344 -567 0 simundump kenz /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR/EGFR-C3G_act 0 0 \ 0 0 0 67857 0.00017684 0.096 0.024 0 1 "" red turquoise "" -1297 -588 0 simundump kreac /kinetics/EGFR_g/pEGFR_g/FRS2_bind_EGFR 1 1.4737e-05 0.2 "" \ white magenta -1314 -562 0 simundump kreac 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xplot /graphs/conc1/NGF.Co 3 524288 \ "delete_plot.w ; edit_plot.D " blue 0 0 1 simundump xgraph /moregraphs/conc3 0 100 3700 0 0.3 0 simundump xgraph /moregraphs/conc4 0 100 3700 0 0.02 0 simundump xcoredraw /edit/draw 0 -1371 -1304 -559.98 -521.28 simundump xtree /edit/draw/tree 0 \ /kinetics/#[],/kinetics/#[]/#[],/kinetics/#[]/#[]/#[][TYPE!=proto],/kinetics/#[]/#[]/#[][TYPE!=linkinfo]/##[] \ "edit_elm.D ; drag_from_edit.w " auto 0.6 simundump xtext /file/notes 0 1 xtextload /file/notes \ "Re-merged with egfr9.g and all115.g" \ "" addmsg /kinetics/Ras_GAP*/kenz /kinetics/Ras-GDP MM_PRD pA addmsg /kinetics/Ras_GAP*/kenz2 /kinetics/Ras-GDP MM_PRD pA addmsg /kinetics/Ras_GAP*/kenz3 /kinetics/Ras-GDP MM_PRD pA addmsg /kinetics/Ras_GTPase /kinetics/Ras-GDP REAC B A addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2/TrkA.Shc.Grb2.Sos_act /kinetics/Ras-GDP REAC sA B addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR/pEGFR_act /kinetics/Ras-GDP REAC sA B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl/pEGFR.c-Cbl_act /kinetics/Ras-GDP REAC sA B addmsg /kinetics/Rap1_GAP/kenz[1] /kinetics/Rap1_GAP REAC eA B addmsg /kinetics/Rap1_GAP/kenz2 /kinetics/Rap1_GAP REAC eA B addmsg /kinetics/Rap1_GAP /kinetics/Rap1_GAP/kenz[1] ENZYME n addmsg /kinetics/TrkA/Rap1GTP /kinetics/Rap1_GAP/kenz[1] SUBSTRATE n addmsg /kinetics/Rap1_GAP /kinetics/Rap1_GAP/kenz2 ENZYME n addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/Rap1_GAP/kenz2 SUBSTRATE n addmsg /kinetics/MAPK/Ras-GTP /kinetics/Ras_GTPase SUBSTRATE n addmsg /kinetics/Ras-GDP /kinetics/Ras_GTPase PRODUCT n addmsg /kinetics/Sos_Grb2/Grb2_bind_Sos /kinetics/Sos_Grb2/Grb2 REAC A B addmsg /kinetics/Sos_Grb2/Grb2_bind_Sos* /kinetics/Sos_Grb2/Grb2 REAC A B addmsg /kinetics/Sos_Grb2/Grb2_bind_Sos /kinetics/Sos_Grb2/Sos REAC A B addmsg /kinetics/Sos_Grb2/dephosph_Sos /kinetics/Sos_Grb2/Sos REAC B A addmsg /kinetics/MAPK/dppErk2_cytosol/kenz[1] /kinetics/Sos_Grb2/Sos REAC sA B addmsg /kinetics/Sos_Grb2/Grb2_bind_Sos* /kinetics/Sos_Grb2/Sos* REAC A B addmsg /kinetics/Sos_Grb2/dephosph_Sos /kinetics/Sos_Grb2/Sos* REAC A B addmsg /kinetics/MAPK/dppErk2_cytosol/kenz[1] /kinetics/Sos_Grb2/Sos* MM_PRD pA addmsg /kinetics/Sos_Grb2/Sos* /kinetics/Sos_Grb2/dephosph_Sos SUBSTRATE n addmsg /kinetics/Sos_Grb2/Sos /kinetics/Sos_Grb2/dephosph_Sos PRODUCT n addmsg /kinetics/Sos_Grb2/Sos* /kinetics/Sos_Grb2/Grb2_bind_Sos* SUBSTRATE n addmsg /kinetics/Sos_Grb2/Grb2 /kinetics/Sos_Grb2/Grb2_bind_Sos* SUBSTRATE n addmsg /kinetics/Sos_Grb2/pSos.Grb2 /kinetics/Sos_Grb2/Grb2_bind_Sos* PRODUCT n addmsg /kinetics/Sos_Grb2/Grb2 /kinetics/Sos_Grb2/Grb2_bind_Sos SUBSTRATE n addmsg /kinetics/Sos_Grb2/Sos.Grb2 /kinetics/Sos_Grb2/Grb2_bind_Sos PRODUCT n addmsg /kinetics/Sos_Grb2/Sos /kinetics/Sos_Grb2/Grb2_bind_Sos SUBSTRATE n addmsg /kinetics/Sos_Grb2/Sos* /kinetics/Sos_Grb2/probe/pSos_total SUMTOTAL n nInit addmsg /kinetics/Sos_Grb2/pSos.Grb2 /kinetics/Sos_Grb2/probe/pSos_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/probe/Sos.pEGFR_total /kinetics/Sos_Grb2/probe/effect_Sos_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/probe/Sos.pTrkA_total /kinetics/Sos_Grb2/probe/effect_Sos_total SUMTOTAL n nInit addmsg /kinetics/Sos_Grb2/Grb2_bind_Sos /kinetics/Sos_Grb2/Sos.Grb2 REAC B A addmsg /kinetics/SHC/pShc_bind_Sos.Grb2 /kinetics/Sos_Grb2/Sos.Grb2 REAC A B addmsg /kinetics/dephosph_Shc[1] /kinetics/Sos_Grb2/Sos.Grb2 REAC B A addmsg /kinetics/MAPK/dppErk2_cytosol/kenz /kinetics/Sos_Grb2/Sos.Grb2 REAC sA B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[5] /kinetics/Sos_Grb2/Sos.Grb2 REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/pShc_bind_Sos.Grb2[1] /kinetics/Sos_Grb2/Sos.Grb2 REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_Sos.Grb2[2] /kinetics/Sos_Grb2/Sos.Grb2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/pShc_bind_Sos.Grb2[3] /kinetics/Sos_Grb2/Sos.Grb2 REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_Sos.Grb2[3] /kinetics/Sos_Grb2/Sos.Grb2 REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/pShc_bind_Sos.Grb2 /kinetics/Sos_Grb2/Sos.Grb2 REAC A B addmsg /kinetics/Sos_Grb2/Grb2_bind_Sos* /kinetics/Sos_Grb2/pSos.Grb2 REAC B A addmsg /kinetics/MAPK/dppErk2_cytosol/kenz /kinetics/Sos_Grb2/pSos.Grb2 MM_PRD pA addmsg /kinetics/MAPK/dppErk2_cytosol/kenz[2] /kinetics/Sos_Grb2/pSos.Grb2 MM_PRD pA addmsg /kinetics/SHC/pShc /kinetics/SHC/dephosph_Shc SUBSTRATE n addmsg /kinetics/SHC/Shc /kinetics/SHC/dephosph_Shc PRODUCT n addmsg /kinetics/SHC/pShc /kinetics/SHC/probe/pShc_total SUMTOTAL n nInit addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/SHC/probe/pShc_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/probe/pShc.pEGFR_total /kinetics/SHC/probe/pShc_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/probe/pShc_total /kinetics/SHC/probe/pShc_total SUMTOTAL n nInit addmsg /kinetics/SHC/Shc /kinetics/SHC/probe/non-pShc_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/probe/non-pShc.pEGFR_total /kinetics/SHC/probe/non-pShc_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/probe/non-pShc_total /kinetics/SHC/probe/non-pShc_total SUMTOTAL n nInit addmsg /kinetics/SHC/probe/non-pShc_total /kinetics/SHC/probe/Shc_total SUMTOTAL n nInit addmsg /kinetics/SHC/probe/pShc_total /kinetics/SHC/probe/Shc_total SUMTOTAL n nInit addmsg /kinetics/SHC/dephosph_Shc /kinetics/SHC/Shc REAC B A addmsg /kinetics/dephosph_Shc[1] /kinetics/SHC/Shc REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/Shc_bind_EGFR /kinetics/SHC/Shc REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_bind_EGFR[1] /kinetics/SHC/Shc REAC A B addmsg /kinetics/TrkA/pTrkA_g/Shc_bind_pTrkA /kinetics/SHC/Shc REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Shc_bind_pTrkA /kinetics/SHC/Shc REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/Shc_bind_EGFR /kinetics/SHC/Shc REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[4] /kinetics/SHC/Shc REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[6] /kinetics/SHC/Shc REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[1] /kinetics/SHC/Shc REAC B A addmsg /kinetics/SHC/dephosph_Shc /kinetics/SHC/pShc REAC A B addmsg /kinetics/SHC/pShc_bind_Sos.Grb2 /kinetics/SHC/pShc REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/pShc_bind_EGFR /kinetics/SHC/pShc REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR[3] /kinetics/SHC/pShc REAC A B addmsg /kinetics/TrkA/pTrkA_g/pShc_bind_pTrkA /kinetics/SHC/pShc REAC A B addmsg /kinetics/MAPK/dppErk2_cytosol/kenz[2] /kinetics/SHC/pShc MM_PRD pA addmsg /kinetics/TrkA/pTrkA_endo_g/pShc_bind_pTrkA /kinetics/SHC/pShc REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_EGFR /kinetics/SHC/pShc REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[5] /kinetics/SHC/pShc REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[3] /kinetics/SHC/pShc REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[2] /kinetics/SHC/pShc REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[3] /kinetics/SHC/pShc REAC B A addmsg /kinetics/Sos_Grb2/Sos.Grb2 /kinetics/SHC/pShc_bind_Sos.Grb2 SUBSTRATE n addmsg /kinetics/SHC/pShc /kinetics/SHC/pShc_bind_Sos.Grb2 SUBSTRATE n addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/SHC/pShc_bind_Sos.Grb2 PRODUCT n addmsg /kinetics/SHC/pShc_bind_Sos.Grb2 /kinetics/SHC/pShc.Sos.Grb2 REAC B A addmsg /kinetics/dephosph_Shc[1] /kinetics/SHC/pShc.Sos.Grb2 REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Grb2_bind_EGFR[1] /kinetics/SHC/pShc.Sos.Grb2 REAC A B addmsg /kinetics/MAPK/dppErk2_cytosol/kenz[2] /kinetics/SHC/pShc.Sos.Grb2 REAC sA B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Grb2_bind_EGFR /kinetics/SHC/pShc.Sos.Grb2 REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR /kinetics/SHC/pShc.Sos.Grb2 REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3 /kinetics/SHC/pShc.Sos.Grb2 REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/pShc.Grb2_bind_pTrkA /kinetics/SHC/pShc.Sos.Grb2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/pShc.Grb2_bind_pTrkA[1] /kinetics/SHC/pShc.Sos.Grb2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[5] /kinetics/SHC/pShc.Sos.Grb2 REAC B A addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/dephosph_Shc[1] SUBSTRATE n addmsg /kinetics/SHC/Shc /kinetics/dephosph_Shc[1] PRODUCT n addmsg /kinetics/Sos_Grb2/Sos.Grb2 /kinetics/dephosph_Shc[1] PRODUCT n addmsg /kinetics/Ras_GAP*/kenz /kinetics/Ras_GAP* REAC eA B addmsg /kinetics/Ras_GAP*/kenz2 /kinetics/Ras_GAP* REAC eA B addmsg /kinetics/Ras_GAP*/kenz3 /kinetics/Ras_GAP* REAC eA B addmsg /kinetics/Dok-RasGAP/ppDok2_bind_RasGAP /kinetics/Ras_GAP* REAC B A addmsg /kinetics/Ras_GAP* /kinetics/Ras_GAP*/kenz ENZYME n addmsg /kinetics/MAPK/Ras-GTP /kinetics/Ras_GAP*/kenz SUBSTRATE n addmsg /kinetics/Ras_GAP* /kinetics/Ras_GAP*/kenz2 ENZYME n addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/Ras_GAP*/kenz2 SUBSTRATE n addmsg /kinetics/Ras_GAP* /kinetics/Ras_GAP*/kenz3 ENZYME n addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/Ras_GAP*/kenz3 SUBSTRATE n addmsg /kinetics/Dok-RasGAP/ppDok2_bind_RasGAP /kinetics/Ras_GAP REAC A B addmsg /kinetics/NGF_ramp/kreac[10] /kinetics/NGF_ramp/GATE REAC A B addmsg /kinetics/NGF_ramp/multiplier /kinetics/NGF_ramp/GATE SLAVE output addmsg /kinetics/NGF_ramp/GATE /kinetics/NGF_ramp/kreac[10] SUBSTRATE n addmsg /kinetics/NGF_ramp/NGF[2] /kinetics/NGF_ramp/kreac[10] PRODUCT n addmsg /kinetics/NGF_ramp/NGF_pulse /kinetics/NGF_ramp/kreac[10] SUBSTRATE n addmsg /kinetics/NGF_ramp/stim_NGF_3ng /kinetics/NGF_ramp/NGF_pulse SLAVE output addmsg /kinetics/NGF_ramp/kreac[10] /kinetics/NGF_ramp/NGF_pulse REAC A B addmsg /kinetics/NGF_ramp/kreac[10] /kinetics/NGF_ramp/NGF[2] REAC B A addmsg /kinetics/U0126_group/U0126_bind_MEK /kinetics/U0126_group/U0126 REAC A B addmsg /kinetics/U0126_group/U0126_bind_MEK_P /kinetics/U0126_group/U0126 REAC A B addmsg /kinetics/U0126_group/U0126_bind_MEK_PP /kinetics/U0126_group/U0126 REAC A B addmsg /kinetics/U0126_group/U0126_bind_MEK /kinetics/U0126_group/U0126.MEK REAC B A addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser /kinetics/U0126_group/U0126.MEK REAC sA B addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser /kinetics/U0126_group/U0126.MEK REAC sA B addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser /kinetics/U0126_group/U0126.MEK REAC sA B addmsg /kinetics/MAPK/PP2A/dephosSer[1] /kinetics/U0126_group/U0126.MEK MM_PRD pA addmsg /kinetics/U0126_group/kreac[1] /kinetics/U0126_group/U0126.MEK REAC A B addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser /kinetics/U0126_group/U0126.MEK_P MM_PRD pA addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser /kinetics/U0126_group/U0126.MEK_P MM_PRD pA addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr /kinetics/U0126_group/U0126.MEK_P REAC sA B addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser /kinetics/U0126_group/U0126.MEK_P MM_PRD pA addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr /kinetics/U0126_group/U0126.MEK_P REAC sA B addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr /kinetics/U0126_group/U0126.MEK_P REAC sA B addmsg /kinetics/MAPK/PP2A/dephosSer[1] /kinetics/U0126_group/U0126.MEK_P REAC sA B addmsg /kinetics/MAPK/PP2A/dephosThr[1] /kinetics/U0126_group/U0126.MEK_P MM_PRD pA addmsg /kinetics/U0126_group/U0126_bind_MEK_P /kinetics/U0126_group/U0126.MEK_P REAC B A addmsg /kinetics/U0126_group/kreac[4] /kinetics/U0126_group/U0126.MEK_P REAC A B addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr /kinetics/U0126_group/U0126.MEK_PP MM_PRD pA addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr /kinetics/U0126_group/U0126.MEK_PP MM_PRD pA addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr /kinetics/U0126_group/U0126.MEK_PP MM_PRD pA addmsg /kinetics/MAPK/PP2A/dephosThr[1] /kinetics/U0126_group/U0126.MEK_PP REAC sA B addmsg /kinetics/U0126_group/U0126_bind_MEK_PP /kinetics/U0126_group/U0126.MEK_PP REAC B A addmsg /kinetics/U0126_group/kreac[9] /kinetics/U0126_group/U0126.MEK_PP REAC A B addmsg /kinetics/U0126_group/kreac[1] /kinetics/U0126_group/U0126.MEK.Erk2 REAC B A addmsg /kinetics/MAPK/PP2A/dephosSer[2] /kinetics/U0126_group/U0126.MEK.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser[1] /kinetics/U0126_group/U0126.MEK.Erk2 REAC sA B addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser[1] /kinetics/U0126_group/U0126.MEK.Erk2 REAC sA B addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser[1] /kinetics/U0126_group/U0126.MEK.Erk2 REAC sA B addmsg /kinetics/U0126_group/kreac[4] /kinetics/U0126_group/U0126.pMEK.Erk2 REAC B A addmsg /kinetics/MAPK/PP2A/dephosSer[2] /kinetics/U0126_group/U0126.pMEK.Erk2 REAC sA B addmsg /kinetics/MAPK/PP2A/dephosThr[2] /kinetics/U0126_group/U0126.pMEK.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser[1] /kinetics/U0126_group/U0126.pMEK.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser[1] /kinetics/U0126_group/U0126.pMEK.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser[1] /kinetics/U0126_group/U0126.pMEK.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr[1] /kinetics/U0126_group/U0126.pMEK.Erk2 REAC sA B addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr[1] /kinetics/U0126_group/U0126.pMEK.Erk2 REAC sA B addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr[1] /kinetics/U0126_group/U0126.pMEK.Erk2 REAC sA B addmsg /kinetics/U0126_group/kreac[9] /kinetics/U0126_group/U0126.ppMEK.Erk2 REAC B A addmsg /kinetics/MAPK/PP2A/dephosThr[2] /kinetics/U0126_group/U0126.ppMEK.Erk2 REAC sA B addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr[1] /kinetics/U0126_group/U0126.ppMEK.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr[1] /kinetics/U0126_group/U0126.ppMEK.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr[1] /kinetics/U0126_group/U0126.ppMEK.Erk2 MM_PRD pA addmsg /kinetics/MAPK/ERK2 /kinetics/U0126_group/kreac[1] SUBSTRATE n addmsg /kinetics/U0126_group/U0126.MEK /kinetics/U0126_group/kreac[1] SUBSTRATE n addmsg /kinetics/U0126_group/U0126.MEK.Erk2 /kinetics/U0126_group/kreac[1] PRODUCT n addmsg /kinetics/U0126_group/U0126 /kinetics/U0126_group/U0126_bind_MEK SUBSTRATE n addmsg /kinetics/MAPK/MEK /kinetics/U0126_group/U0126_bind_MEK SUBSTRATE n addmsg /kinetics/U0126_group/U0126.MEK /kinetics/U0126_group/U0126_bind_MEK PRODUCT n addmsg /kinetics/U0126_group/U0126 /kinetics/U0126_group/U0126_bind_MEK_P SUBSTRATE n addmsg /kinetics/MAPK/MEK_P /kinetics/U0126_group/U0126_bind_MEK_P SUBSTRATE n addmsg /kinetics/U0126_group/U0126.MEK_P /kinetics/U0126_group/U0126_bind_MEK_P PRODUCT n addmsg /kinetics/U0126_group/U0126.MEK_P /kinetics/U0126_group/kreac[4] SUBSTRATE n addmsg /kinetics/U0126_group/U0126.pMEK.Erk2 /kinetics/U0126_group/kreac[4] PRODUCT n addmsg /kinetics/MAPK/ERK2 /kinetics/U0126_group/kreac[4] SUBSTRATE n addmsg /kinetics/U0126_group/U0126.MEK_PP /kinetics/U0126_group/kreac[9] SUBSTRATE n addmsg /kinetics/MAPK/ERK2 /kinetics/U0126_group/kreac[9] SUBSTRATE n addmsg /kinetics/U0126_group/U0126.ppMEK.Erk2 /kinetics/U0126_group/kreac[9] PRODUCT n addmsg /kinetics/MAPK/probe/Rap1_B-Raf_in-complex /kinetics/U0126_group/kreac[9] PRODUCT n addmsg /kinetics/U0126_group/U0126 /kinetics/U0126_group/U0126_bind_MEK_PP SUBSTRATE n addmsg /kinetics/MAPK/MEK_PP /kinetics/U0126_group/U0126_bind_MEK_PP SUBSTRATE n addmsg /kinetics/U0126_group/U0126.MEK_PP /kinetics/U0126_group/U0126_bind_MEK_PP PRODUCT n addmsg /kinetics/TrkA/degradation /kinetics/TrkA/endo_TrkA REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[1] /kinetics/TrkA/endo_TrkA REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[2] /kinetics/TrkA/endo_TrkA REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[3] /kinetics/TrkA/endo_TrkA REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3 /kinetics/TrkA/endo_TrkA REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[4] /kinetics/TrkA/endo_TrkA REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[5] /kinetics/TrkA/endo_TrkA REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[6] /kinetics/TrkA/endo_TrkA REAC B A addmsg /kinetics/Rap1.GDP /kinetics/TrkA/GTPase PRODUCT n addmsg /kinetics/TrkA/Rap1GTP /kinetics/TrkA/GTPase SUBSTRATE n addmsg /kinetics/TrkA/L.dpTrkA /kinetics/TrkA/autophosphorylation PRODUCT n addmsg /kinetics/TrkA/L.TrkA /kinetics/TrkA/autophosphorylation SUBSTRATE n addmsg /kinetics/TrkA/autophosphorylation /kinetics/TrkA/L.TrkA REAC A B addmsg /kinetics/TrkA/kreac /kinetics/TrkA/L.TrkA REAC B A addmsg /kinetics/TrkA/kreac /kinetics/TrkA/NGF REAC A B addmsg /kinetics/TrkA/endo_TrkA /kinetics/TrkA/degradation SUBSTRATE n addmsg /kinetics/TrkA/Buffer /kinetics/TrkA/degradation PRODUCT n addmsg /kinetics/TrkA/Glycocyl_transferase/glycosylation /kinetics/TrkA/Glycocyl_transferase REAC eA B addmsg /kinetics/TrkA/Glycocyl_transferase /kinetics/TrkA/Glycocyl_transferase/glycosylation ENZYME n addmsg /kinetics/TrkA/degradation /kinetics/TrkA/Buffer REAC B A addmsg /kinetics/TrkA/degradation2 /kinetics/TrkA/Buffer REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph /kinetics/TrkA/Buffer REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[1] /kinetics/TrkA/Buffer REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[2] /kinetics/TrkA/Buffer REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[3] /kinetics/TrkA/Buffer REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[4] /kinetics/TrkA/Buffer REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[5] /kinetics/TrkA/Buffer REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[6] /kinetics/TrkA/Buffer REAC B A addmsg /kinetics/TrkA/Buffer /kinetics/TrkA/degradation2 PRODUCT n addmsg /kinetics/TrkA/NGFR /kinetics/TrkA/degradation2 SUBSTRATE n addmsg /kinetics/TrkA/endo_TrkA /kinetics/TrkA/sum_non_phospho_TrkA SUMTOTAL n nInit addmsg /kinetics/TrkA/L.TrkA /kinetics/TrkA/sum_non_phospho_TrkA SUMTOTAL n nInit addmsg /kinetics/TrkA/NGFR /kinetics/TrkA/sum_non_phospho_TrkA SUMTOTAL n nInit addmsg /kinetics/TrkA/pro-TrkA /kinetics/TrkA/TrkA_synthesis SUBSTRATE n addmsg /kinetics/TrkA/NGFR /kinetics/TrkA/TrkA_synthesis PRODUCT n addmsg /kinetics/TrkA/TrkA_synthesis /kinetics/TrkA/pro-TrkA REAC A B addmsg /kinetics/FRS2_g/pFRS2 /kinetics/TrkA/dephospho_FRS2 SUBSTRATE n addmsg /kinetics/FRS2_g/FRS2 /kinetics/TrkA/dephospho_FRS2 PRODUCT n addmsg /kinetics/TrkA/autophosphorylation /kinetics/TrkA/L.dpTrkA REAC B A addmsg /kinetics/TrkA/pTrkA_g/pShc_bind_pTrkA /kinetics/TrkA/L.dpTrkA REAC A B addmsg /kinetics/TrkA/pTrkA_g/pFRS2_bind_pTrkA /kinetics/TrkA/L.dpTrkA REAC A B addmsg /kinetics/TrkA/pTrkA_g/Shc_bind_pTrkA /kinetics/TrkA/L.dpTrkA REAC A B addmsg /kinetics/TrkA/pTrkA_g/FRS2_bind_pTrkA /kinetics/TrkA/L.dpTrkA REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[4] /kinetics/TrkA/L.dpTrkA REAC A B addmsg /kinetics/TrkA/pTrkA_g/pShc.Grb2_bind_pTrkA[1] /kinetics/TrkA/L.dpTrkA REAC A B addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph /kinetics/TrkA/L.dpTrkA REAC A B addmsg /kinetics/TrkA/sum_non_phospho_TrkA /kinetics/TrkA/TrkA_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_total /kinetics/TrkA/TrkA_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/probe/pTrkA_endo_total /kinetics/TrkA/pTrkA_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr /kinetics/TrkA/pTrkA_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/Crk_bind_pFRS2 /kinetics/TrkA/Crk.C3G REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation /kinetics/TrkA/Crk.C3G REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[3] /kinetics/TrkA/Crk.C3G REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/Crk_bind_pFRS2[1] /kinetics/TrkA/Crk.C3G REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/FRS2_bind_Crk /kinetics/TrkA/Crk.C3G REAC A B addmsg /kinetics/TrkA/Crk_bind_C3G /kinetics/TrkA/Crk.C3G REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_Crk[1] /kinetics/TrkA/Crk.C3G REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_Crk[1] /kinetics/TrkA/Crk.C3G REAC A B addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[6] /kinetics/TrkA/Crk.C3G REAC B A addmsg /kinetics/TrkA/Crk_bind_C3G /kinetics/TrkA/Crk REAC A B addmsg /kinetics/TrkA/Crk_bind_C3G /kinetics/TrkA/C3G REAC A B addmsg /kinetics/TrkA/C3G /kinetics/TrkA/Crk_bind_C3G SUBSTRATE n addmsg /kinetics/TrkA/Crk /kinetics/TrkA/Crk_bind_C3G SUBSTRATE n addmsg /kinetics/TrkA/Crk.C3G /kinetics/TrkA/Crk_bind_C3G PRODUCT n addmsg /kinetics/TrkA/GTPase /kinetics/TrkA/Rap1GTP REAC A B addmsg /kinetics/Rap1_GAP/kenz[1] /kinetics/TrkA/Rap1GTP REAC sA B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl/EGFR.C3G.c-Cbl_act /kinetics/TrkA/Rap1GTP MM_PRD pA addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR/EGFR-C3G_act /kinetics/TrkA/Rap1GTP MM_PRD pA addmsg /kinetics/MAPK/Rap1_bind_B-Raf /kinetics/TrkA/Rap1GTP REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo/TrkA-C3G_act /kinetics/TrkA/Rap1GTP MM_PRD pA addmsg /kinetics/TrkA/Rap1GTP /kinetics/TrkA/Rap1.GTP_total SUMTOTAL n nInit addmsg /kinetics/Rap1_GAP/kenz[1] /kinetics/TrkA/Rap1.GTP_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/TrkA/pTrkA_g/FRS2_Tyr_phosphory /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/FRS2_bind_pTrkA /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[5] /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[2] /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 /kinetics/TrkA/pTrkA_g/FRS2_Tyr_phosphory SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 /kinetics/TrkA/pTrkA_g/FRS2_Tyr_phosphory PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/pFRS2_bind_pTrkA /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 REAC B A addmsg /kinetics/TrkA/pTrkA_g/FRS2_Tyr_phosphory /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 REAC B A addmsg /kinetics/TrkA/pTrkA_g/Crk_bind_pFRS2 /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[4] /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 REAC A B addmsg /kinetics/TrkA/L.dpTrkA /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2.Crk.C3G_membr /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.Shc /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr/TrkA_act_Dok ENZYME n addmsg /kinetics/Dok-RasGAP/Dok2 /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr/TrkA_act_Dok SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc /kinetics/TrkA/pTrkA_g/probe/pShc_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_g/probe/pShc_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo /kinetics/TrkA/pTrkA_g/probe/pShc_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo /kinetics/TrkA/pTrkA_g/probe/pShc_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.Shc /kinetics/TrkA/pTrkA_g/probe/non-pShc_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo /kinetics/TrkA/pTrkA_g/probe/non-pShc_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr /kinetics/TrkA/pTrkA_g/probe/TrkA_surface SUMTOTAL n nInit addmsg /kinetics/TrkA/L.TrkA /kinetics/TrkA/pTrkA_g/probe/TrkA_surface SUMTOTAL n nInit addmsg /kinetics/TrkA/NGFR /kinetics/TrkA/pTrkA_g/probe/TrkA_surface SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_g/probe/Sos.pTrkA_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/Crk_bind_pFRS2 /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2.Crk.C3G_membr REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[2] /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2.Crk.C3G_membr REAC A B addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[6] /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2.Crk.C3G_membr REAC A B addmsg /kinetics/TrkA/pTrkA_g/pShc_bind_Sos.Grb2[3] /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[3] /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/pShc.Grb2_bind_pTrkA[1] /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[5] /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2/TrkA.Shc.Grb2.Sos_act ENZYME n addmsg /kinetics/Ras-GDP /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2/TrkA.Shc.Grb2.Sos_act SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/Shc_bind_pTrkA /kinetics/TrkA/pTrkA_g/pTrkA.Shc REAC B A addmsg /kinetics/TrkA/pTrkA_g/Shc_Tyr_phosphory /kinetics/TrkA/pTrkA_g/pTrkA.Shc REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[6] /kinetics/TrkA/pTrkA_g/pTrkA.Shc REAC A B addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[1] /kinetics/TrkA/pTrkA_g/pTrkA.Shc REAC A B addmsg /kinetics/TrkA/pTrkA_g/pShc_bind_pTrkA /kinetics/TrkA/pTrkA_g/pTrkA.pShc REAC B A addmsg /kinetics/TrkA/pTrkA_g/pShc_bind_Sos.Grb2[3] /kinetics/TrkA/pTrkA_g/pTrkA.pShc REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[1] /kinetics/TrkA/pTrkA_g/pTrkA.pShc REAC A B addmsg /kinetics/TrkA/pTrkA_g/Shc_Tyr_phosphory /kinetics/TrkA/pTrkA_g/pTrkA.pShc REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[3] /kinetics/TrkA/pTrkA_g/pTrkA.pShc REAC A B addmsg /kinetics/TrkA/pTrkA_g/pTrkA.Shc /kinetics/TrkA/pTrkA_g/Shc_Tyr_phosphory SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc /kinetics/TrkA/pTrkA_g/Shc_Tyr_phosphory PRODUCT n addmsg /kinetics/FRS2_g/FRS2 /kinetics/TrkA/pTrkA_g/FRS2_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/L.dpTrkA /kinetics/TrkA/pTrkA_g/FRS2_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 /kinetics/TrkA/pTrkA_g/FRS2_bind_pTrkA PRODUCT n addmsg /kinetics/TrkA/Crk.C3G /kinetics/TrkA/pTrkA_g/Crk_bind_pFRS2 SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2.Crk.C3G_membr /kinetics/TrkA/pTrkA_g/Crk_bind_pFRS2 PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 /kinetics/TrkA/pTrkA_g/Crk_bind_pFRS2 SUBSTRATE n addmsg /kinetics/FRS2_g/pFRS2 /kinetics/TrkA/pTrkA_g/pFRS2_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 /kinetics/TrkA/pTrkA_g/pFRS2_bind_pTrkA PRODUCT n addmsg /kinetics/TrkA/L.dpTrkA /kinetics/TrkA/pTrkA_g/pFRS2_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/L.dpTrkA /kinetics/TrkA/pTrkA_g/Shc_bind_pTrkA SUBSTRATE n addmsg /kinetics/SHC/Shc /kinetics/TrkA/pTrkA_g/Shc_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.Shc /kinetics/TrkA/pTrkA_g/Shc_bind_pTrkA PRODUCT n addmsg /kinetics/TrkA/L.dpTrkA /kinetics/TrkA/pTrkA_g/pShc_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc /kinetics/TrkA/pTrkA_g/pShc_bind_pTrkA PRODUCT n addmsg /kinetics/SHC/pShc /kinetics/TrkA/pTrkA_g/pShc_bind_pTrkA SUBSTRATE n addmsg /kinetics/Sos_Grb2/Sos.Grb2 /kinetics/TrkA/pTrkA_g/pShc_bind_Sos.Grb2[3] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc /kinetics/TrkA/pTrkA_g/pShc_bind_Sos.Grb2[3] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_g/pShc_bind_Sos.Grb2[3] PRODUCT n addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_g/pShc.Grb2_bind_pTrkA[1] SUBSTRATE n addmsg /kinetics/TrkA/L.dpTrkA /kinetics/TrkA/pTrkA_g/pShc.Grb2_bind_pTrkA[1] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_g/pShc.Grb2_bind_pTrkA[1] PRODUCT n addmsg /kinetics/TrkA/L.dpTrkA /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph SUBSTRATE n addmsg /kinetics/TrkA/Buffer /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.Shc /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[1] SUBSTRATE n addmsg /kinetics/TrkA/Buffer /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[1] PRODUCT n addmsg /kinetics/SHC/Shc /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[1] PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[2] SUBSTRATE n addmsg /kinetics/FRS2_g/FRS2 /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[2] PRODUCT n addmsg /kinetics/TrkA/Buffer /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[2] PRODUCT n addmsg /kinetics/TrkA/Buffer /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[3] PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[3] SUBSTRATE n addmsg /kinetics/SHC/pShc /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[3] PRODUCT n addmsg /kinetics/TrkA/Buffer /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[4] PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[4] SUBSTRATE n addmsg /kinetics/FRS2_g/pFRS2 /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[4] PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[5] SUBSTRATE n addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[5] PRODUCT n addmsg /kinetics/TrkA/Buffer /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[5] PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2.Crk.C3G_membr /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[6] SUBSTRATE n addmsg /kinetics/FRS2_g/pFRS2 /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[6] PRODUCT n addmsg /kinetics/TrkA/Crk.C3G /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[6] PRODUCT n addmsg /kinetics/TrkA/Buffer /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[6] PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc /kinetics/TrkA/pTrkA_endo_g/Internalization[1] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo /kinetics/TrkA/pTrkA_endo_g/Internalization[1] PRODUCT n addmsg /kinetics/TrkA/L.dpTrkA /kinetics/TrkA/pTrkA_endo_g/Internalization[4] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo /kinetics/TrkA/pTrkA_endo_g/Internalization[4] PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2.Crk.C3G_membr /kinetics/TrkA/pTrkA_endo_g/Internalization[2] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo /kinetics/TrkA/pTrkA_endo_g/Internalization[2] PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 /kinetics/TrkA/pTrkA_endo_g/Internalization[5] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo /kinetics/TrkA/pTrkA_endo_g/Internalization[5] PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 /kinetics/TrkA/pTrkA_endo_g/Internalization SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo /kinetics/TrkA/pTrkA_endo_g/Internalization PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_endo_g/Internalization[3] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo /kinetics/TrkA/pTrkA_endo_g/Internalization[3] PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo /kinetics/TrkA/pTrkA_endo_g/Shc_Tyr_phosphory[1] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo /kinetics/TrkA/pTrkA_endo_g/Shc_Tyr_phosphory[1] PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo /kinetics/TrkA/pTrkA_endo_g/FRS2_Tyr_phosphory[1] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo /kinetics/TrkA/pTrkA_endo_g/FRS2_Tyr_phosphory[1] PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[4] /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/FRS2_bind_pTrkA[1] /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Shc_bind_pTrkA /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/pShc_bind_pTrkA /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/pFRS2_bind_pTrkA[1] /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[5] /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/pShc.Grb2_bind_pTrkA /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo REAC A B addmsg /kinetics/TrkA/Crk.C3G /kinetics/TrkA/pTrkA_endo_g/Crk_bind_pFRS2[1] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo /kinetics/TrkA/pTrkA_endo_g/Crk_bind_pFRS2[1] PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo /kinetics/TrkA/pTrkA_endo_g/Crk_bind_pFRS2[1] SUBSTRATE n addmsg /kinetics/FRS2_g/pFRS2 /kinetics/TrkA/pTrkA_endo_g/pFRS2_bind_pTrkA[1] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo /kinetics/TrkA/pTrkA_endo_g/pFRS2_bind_pTrkA[1] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo /kinetics/TrkA/pTrkA_endo_g/pFRS2_bind_pTrkA[1] PRODUCT n addmsg /kinetics/FRS2_g/FRS2 /kinetics/TrkA/pTrkA_endo_g/FRS2_bind_pTrkA[1] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo /kinetics/TrkA/pTrkA_endo_g/FRS2_bind_pTrkA[1] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo /kinetics/TrkA/pTrkA_endo_g/FRS2_bind_pTrkA[1] PRODUCT n addmsg /kinetics/SHC/pShc /kinetics/TrkA/pTrkA_endo_g/pShc_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo /kinetics/TrkA/pTrkA_endo_g/pShc_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo /kinetics/TrkA/pTrkA_endo_g/pShc_bind_pTrkA PRODUCT n addmsg /kinetics/SHC/Shc /kinetics/TrkA/pTrkA_endo_g/Shc_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo /kinetics/TrkA/pTrkA_endo_g/Shc_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo /kinetics/TrkA/pTrkA_endo_g/Shc_bind_pTrkA PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo /kinetics/TrkA/pTrkA_endo_g/pShc_bind_Sos.Grb2 SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo /kinetics/TrkA/pTrkA_endo_g/pShc_bind_Sos.Grb2 PRODUCT n addmsg /kinetics/Sos_Grb2/Sos.Grb2 /kinetics/TrkA/pTrkA_endo_g/pShc_bind_Sos.Grb2 SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[1] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[2] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/pShc_bind_pTrkA /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/pShc_bind_Sos.Grb2 /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Shc_Tyr_phosphory[1] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/Shc_bind_pTrkA /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/Shc_Tyr_phosphory[1] /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[6] /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[6] /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[3] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3 /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/pShc_bind_Sos.Grb2 /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/pShc.Grb2_bind_pTrkA /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[2] SUBSTRATE n addmsg /kinetics/TrkA/endo_TrkA /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[2] PRODUCT n addmsg /kinetics/SHC/pShc /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[2] PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3 SUBSTRATE n addmsg /kinetics/TrkA/endo_TrkA /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3 PRODUCT n addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3 PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[3] SUBSTRATE n addmsg /kinetics/TrkA/endo_TrkA /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[3] PRODUCT n addmsg /kinetics/TrkA/Crk.C3G /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[3] PRODUCT n addmsg /kinetics/FRS2_g/pFRS2 /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[3] PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[1] SUBSTRATE n addmsg /kinetics/TrkA/endo_TrkA /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[1] PRODUCT n addmsg /kinetics/FRS2_g/pFRS2 /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[1] PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[4] SUBSTRATE n addmsg /kinetics/TrkA/endo_TrkA /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[4] PRODUCT n addmsg /kinetics/FRS2_g/FRS2 /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[4] PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[2] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[3] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Crk_bind_pFRS2[1] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo/TrkA-C3G_act ENZYME n addmsg /kinetics/Rap1.GDP /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo/TrkA-C3G_act SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/FRS2_Tyr_phosphory[1] /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization[5] /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/FRS2_bind_pTrkA[1] /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[4] /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Internalization /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[1] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/Crk_bind_pFRS2[1] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/FRS2_Tyr_phosphory[1] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/pFRS2_bind_pTrkA[1] /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[5] SUBSTRATE n addmsg /kinetics/TrkA/endo_TrkA /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[5] PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[6] SUBSTRATE n addmsg /kinetics/TrkA/endo_TrkA /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[6] PRODUCT n addmsg /kinetics/SHC/Shc /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[6] PRODUCT n addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/TrkA/pTrkA_endo_g/pShc.Grb2_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo /kinetics/TrkA/pTrkA_endo_g/pShc.Grb2_bind_pTrkA SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo /kinetics/TrkA/pTrkA_endo_g/pShc.Grb2_bind_pTrkA PRODUCT n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo /kinetics/TrkA/pTrkA_endo_g/probe/pTrkA_endo_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc_endo /kinetics/TrkA/pTrkA_endo_g/probe/pTrkA_endo_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo /kinetics/TrkA/pTrkA_endo_g/probe/pTrkA_endo_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo /kinetics/TrkA/pTrkA_endo_g/probe/pTrkA_endo_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo /kinetics/TrkA/pTrkA_endo_g/probe/pTrkA_endo_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/L.dpTrkA_endo /kinetics/TrkA/pTrkA_endo_g/probe/pTrkA_endo_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pShc.Sos.Grb2_endo /kinetics/TrkA/pTrkA_endo_g/probe/pTrkA_endo_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.Shc /kinetics/TrkA/pTrkA_endo_g/Internalization[6] SUBSTRATE n addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.Shc_endo /kinetics/TrkA/pTrkA_endo_g/Internalization[6] PRODUCT n addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2 /kinetics/TrkA/pFRS2_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2_endo /kinetics/TrkA/pFRS2_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo /kinetics/TrkA/pFRS2_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pFRS2.Crk.C3G_membr /kinetics/TrkA/pFRS2_total SUMTOTAL n nInit addmsg /kinetics/TrkA/NGFR /kinetics/TrkA/kreac SUBSTRATE n addmsg /kinetics/TrkA/NGF /kinetics/TrkA/kreac SUBSTRATE n addmsg /kinetics/TrkA/L.TrkA /kinetics/TrkA/kreac PRODUCT n addmsg /kinetics/TrkA/TrkA_synthesis /kinetics/TrkA/NGFR REAC B A addmsg /kinetics/TrkA/degradation2 /kinetics/TrkA/NGFR REAC A B addmsg /kinetics/TrkA/kreac /kinetics/TrkA/NGFR REAC A B addmsg /kinetics/kreac /kinetics/TrkA/NGF[1] REAC B A addmsg /kinetics/kreac /kinetics/TrkA/NGF[2] REAC A B addmsg /kinetics/TrkA/stim_NGF_5ng[1] /kinetics/TrkA/NGF[2] SLAVE output addmsg /kinetics/TrkA/stim_NGF_gate /kinetics/TrkA/NGF[3] SLAVE output addmsg /kinetics/kreac /kinetics/TrkA/NGF[3] REAC A B addmsg /kinetics/TrkA/stim_NGF_1ng[1] /kinetics/TrkA/NGF[4] SLAVE output addmsg /kinetics/TrkA/NGF[4] /kinetics/TrkA/NGF[5] SUMTOTAL n nInit addmsg /kinetics/TrkA/NGF[1] /kinetics/TrkA/NGF[5] SUMTOTAL n nInit addmsg /kinetics/MAPK/ERK2-PP /kinetics/MAPK/probe/ERK2-PP_total SUMTOTAL n nInit addmsg /kinetics/MAPK/dppErk2_cytosol /kinetics/MAPK/probe/ERK2-PP_total SUMTOTAL n nInit addmsg /kinetics/MAPK/dppErk2_cytosol/kenz /kinetics/MAPK/probe/ERK2-PP_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/dppErk2_cytosol/kenz[1] /kinetics/MAPK/probe/ERK2-PP_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph /kinetics/MAPK/probe/ERK2-PP_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph_dppErk /kinetics/MAPK/probe/ERK2-PP_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/probe/dppErk2_cytosol_dummy /kinetics/MAPK/probe/ERK2-PP_total SUMTOTAL n nInit addmsg /kinetics/MAPK/probe/dppErk2_cytosol_dummy[1] /kinetics/MAPK/probe/ERK2-PP_total SUMTOTAL n nInit addmsg /kinetics/TrkA/Rap1.GTP_total /kinetics/MAPK/probe/Rap1-GTP_total SUMTOTAL n nInit addmsg /kinetics/MAPK/probe/Rap1_B-Raf_total /kinetics/MAPK/probe/Rap1-GTP_total SUMTOTAL n nInit addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/MAPK/probe/Ras_B-Raf_total SUMTOTAL n nInit addmsg /kinetics/Ras_GAP*/kenz2 /kinetics/MAPK/probe/Ras_B-Raf_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/probe/Ras_B-Raf_in-complex /kinetics/MAPK/probe/Ras_B-Raf_total SUMTOTAL n nInit addmsg /kinetics/MAPK/Ras-GTP /kinetics/MAPK/probe/Ras-GTP_total SUMTOTAL n nInit addmsg /kinetics/MAPK/probe/Ras_C-Raf_total /kinetics/MAPK/probe/Ras-GTP_total SUMTOTAL n nInit addmsg /kinetics/MAPK/probe/Ras_B-Raf_total /kinetics/MAPK/probe/Ras-GTP_total SUMTOTAL n nInit addmsg /kinetics/Ras_GAP*/kenz /kinetics/MAPK/probe/Ras-GTP_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/U0126_group/U0126.MEK_P /kinetics/MAPK/probe/pMEK_total SUMTOTAL n nInit addmsg /kinetics/U0126_group/U0126.pMEK.Erk2 /kinetics/MAPK/probe/pMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/MEK_P /kinetics/MAPK/probe/pMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/MEK_P.Erk2 /kinetics/MAPK/probe/pMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/probe/pMEK_in-complex /kinetics/MAPK/probe/pMEK_total SUMTOTAL n nInit addmsg /kinetics/U0126_group/U0126.MEK /kinetics/MAPK/probe/non-pMEK_total SUMTOTAL n nInit addmsg /kinetics/U0126_group/U0126.MEK.Erk2 /kinetics/MAPK/probe/non-pMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/MEK /kinetics/MAPK/probe/non-pMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/MEK.Erk2 /kinetics/MAPK/probe/non-pMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/probe/non-pMEK_in-complex /kinetics/MAPK/probe/non-pMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser[1] /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser[1] /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser[1] /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/ser /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/ser /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/ser /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/ser[1] /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/ser[1] /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/ser[1] /kinetics/MAPK/probe/non-pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr[1] /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr[1] /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr[1] /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/PP2A/dephosSer[1] /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/PP2A/dephosSer[2] /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/PP2A/dephosSer /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/PP2A/dephosSer_pMEK.Erk2 /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/thr /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/thr /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/thr /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/thr[1] /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/thr[1] /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/thr[1] /kinetics/MAPK/probe/pMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/PP2A/dephosThr[1] /kinetics/MAPK/probe/ppMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/PP2A/dephosThr[2] /kinetics/MAPK/probe/ppMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/PP2A/dephosThr_ppMEK.Erk2 /kinetics/MAPK/probe/ppMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/PP2A/dephosThr /kinetics/MAPK/probe/ppMEK_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/U0126_group/U0126.ppMEK.Erk2 /kinetics/MAPK/probe/ppMEK_total SUMTOTAL n nInit addmsg /kinetics/U0126_group/U0126.MEK_PP /kinetics/MAPK/probe/ppMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/MEK_PP /kinetics/MAPK/probe/ppMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/MEK_PP.Erk2 /kinetics/MAPK/probe/ppMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/probe/ppMEK_in-complex /kinetics/MAPK/probe/ppMEK_total SUMTOTAL n nInit addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/MAPK/probe/Ras_C-Raf_total SUMTOTAL n nInit addmsg /kinetics/Ras_GAP*/kenz3 /kinetics/MAPK/probe/Ras_C-Raf_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/probe/Ras_C-Raf_in-complex /kinetics/MAPK/probe/Ras_C-Raf_total SUMTOTAL n nInit addmsg /kinetics/MAPK/Ras_B-Raf/ser /kinetics/MAPK/probe/Ras_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/thr /kinetics/MAPK/probe/Ras_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/ser[1] /kinetics/MAPK/probe/Ras_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/thr[1] /kinetics/MAPK/probe/Ras_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr /kinetics/MAPK/probe/Ras_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser /kinetics/MAPK/probe/Ras_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser[1] /kinetics/MAPK/probe/Ras_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr[1] /kinetics/MAPK/probe/Ras_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser /kinetics/MAPK/probe/Ras_C-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr /kinetics/MAPK/probe/Ras_C-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser[1] /kinetics/MAPK/probe/Ras_C-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr[1] /kinetics/MAPK/probe/Ras_C-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/ser /kinetics/MAPK/probe/Ras_C-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/thr /kinetics/MAPK/probe/Ras_C-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/ser[1] /kinetics/MAPK/probe/Ras_C-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/thr[1] /kinetics/MAPK/probe/Ras_C-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/thr /kinetics/MAPK/probe/Rap1_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/ser /kinetics/MAPK/probe/Rap1_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/ser[1] /kinetics/MAPK/probe/Rap1_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/thr[1] /kinetics/MAPK/probe/Rap1_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr /kinetics/MAPK/probe/Rap1_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/U0126_group/kreac[9] /kinetics/MAPK/probe/Rap1_B-Raf_in-complex REAC B A addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr[1] /kinetics/MAPK/probe/Rap1_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser /kinetics/MAPK/probe/Rap1_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser[1] /kinetics/MAPK/probe/Rap1_B-Raf_in-complex SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/dppErk2_cytosol/kenz /kinetics/MAPK/probe/dppErk2_cytosol_dummy SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/dppErk2_cytosol/kenz[1] /kinetics/MAPK/probe/dppErk2_cytosol_dummy SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/dppErk2_cytosol/kenz[2] /kinetics/MAPK/probe/dppErk2_cytosol_dummy SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/MEK_PP.Erk2 /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL n nInit addmsg /kinetics/MAPK/MEK_P.Erk2 /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL n nInit addmsg /kinetics/MAPK/MEK.Erk2 /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL n nInit addmsg /kinetics/MAPK/ERK2 /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL n nInit addmsg /kinetics/MAPK/Rap1_B-Raf/thr[1] /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/thr[1] /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/thr[1] /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/PP2A/dephosThr_ppMEK.Erk2 /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf/ser[1] /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_B-Raf/ser[1] /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Ras_C-Raf/ser[1] /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/PP2A/dephosSer_pMEK.Erk2 /kinetics/MAPK/probe/non-pERK2_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/probe/non-pERK2_total /kinetics/MAPK/probe/any_ERK2_total SUMTOTAL n nInit addmsg /kinetics/MAPK/probe/ERK2-PP_total /kinetics/MAPK/probe/any_ERK2_total SUMTOTAL n nInit addmsg /kinetics/MAPK/dppErk2_cytosol /kinetics/MAPK/probe/dppErk2_cytosol_dummy[1] SUMTOTAL n nInit addmsg /kinetics/MAPK/probe/dppErk2_cytosol_dummy /kinetics/MAPK/probe/dppErk2_cytosol_dummy[1] SUMTOTAL n nInit addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph_dppErk /kinetics/MAPK/probe/dppErk2_cytosol_dummy[1] SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph /kinetics/MAPK/probe/dppErk2_cytosol_dummy[1] SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/MAPK/probe/Rap1_B-Raf_total SUMTOTAL n nInit addmsg /kinetics/MAPK/probe/Rap1_B-Raf_in-complex /kinetics/MAPK/probe/Rap1_B-Raf_total SUMTOTAL n nInit addmsg /kinetics/Rap1_GAP/kenz2 /kinetics/MAPK/probe/Rap1_B-Raf_total SUMTOTAL nComplex nComplexInit addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph /kinetics/MAPK/MKP3 REAC eA B addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph_dppErk /kinetics/MAPK/MKP3 REAC eA B addmsg /kinetics/MAPK/MKP3 /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph ENZYME n addmsg /kinetics/MAPK/ERK2-PP /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph SUBSTRATE n addmsg /kinetics/MAPK/MKP3 /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph_dppErk ENZYME n addmsg /kinetics/MAPK/dppErk2_cytosol /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph_dppErk SUBSTRATE n addmsg /kinetics/MAPK/ppMEK_act_Erk2 /kinetics/MAPK/MEK_PP.Erk2 REAC A B addmsg /kinetics/MAPK/kreac /kinetics/MAPK/MEK_PP.Erk2 REAC B A addmsg /kinetics/MAPK/PP2A/dephosThr_ppMEK.Erk2 /kinetics/MAPK/MEK_PP.Erk2 REAC sA B addmsg /kinetics/MAPK/Ras_C-Raf/thr[1] /kinetics/MAPK/MEK_PP.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Ras_B-Raf/thr[1] /kinetics/MAPK/MEK_PP.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Rap1_B-Raf/thr[1] /kinetics/MAPK/MEK_PP.Erk2 MM_PRD pA addmsg /kinetics/MAPK/PP2A/dephosThr_ppMEK.Erk2 /kinetics/MAPK/MEK_P.Erk2 MM_PRD pA addmsg /kinetics/MAPK/kreac[8] /kinetics/MAPK/MEK_P.Erk2 REAC B A addmsg /kinetics/MAPK/PP2A/dephosSer_pMEK.Erk2 /kinetics/MAPK/MEK_P.Erk2 REAC sA B addmsg /kinetics/MAPK/Ras_C-Raf/thr[1] /kinetics/MAPK/MEK_P.Erk2 REAC sA B addmsg /kinetics/MAPK/Ras_B-Raf/ser[1] /kinetics/MAPK/MEK_P.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Ras_B-Raf/thr[1] /kinetics/MAPK/MEK_P.Erk2 REAC sA B addmsg /kinetics/MAPK/Rap1_B-Raf/ser[1] /kinetics/MAPK/MEK_P.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Rap1_B-Raf/thr[1] /kinetics/MAPK/MEK_P.Erk2 REAC sA B addmsg /kinetics/MAPK/Ras_C-Raf/ser[1] /kinetics/MAPK/MEK_P.Erk2 MM_PRD pA addmsg /kinetics/MAPK/kreac[2] /kinetics/MAPK/MEK.Erk2 REAC B A addmsg /kinetics/MAPK/PP2A/dephosSer_pMEK.Erk2 /kinetics/MAPK/MEK.Erk2 MM_PRD pA addmsg /kinetics/MAPK/Ras_C-Raf/ser[1] /kinetics/MAPK/MEK.Erk2 REAC sA B addmsg /kinetics/MAPK/Ras_B-Raf/ser[1] /kinetics/MAPK/MEK.Erk2 REAC sA B addmsg /kinetics/MAPK/Rap1_B-Raf/ser[1] /kinetics/MAPK/MEK.Erk2 REAC sA B addmsg /kinetics/MAPK/Ras_B-Raf/ser /kinetics/MAPK/MEK REAC sA B addmsg /kinetics/MAPK/Ras_C-Raf/ser /kinetics/MAPK/MEK REAC sA B addmsg /kinetics/MAPK/PP2A/dephosSer /kinetics/MAPK/MEK MM_PRD pA addmsg /kinetics/MAPK/Rap1_B-Raf/ser /kinetics/MAPK/MEK REAC sA B addmsg /kinetics/U0126_group/U0126_bind_MEK /kinetics/MAPK/MEK REAC A B addmsg /kinetics/MAPK/kreac[2] /kinetics/MAPK/MEK REAC A B addmsg /kinetics/MAPK/Ras_B-Raf/ser /kinetics/MAPK/MEK_P MM_PRD pA addmsg /kinetics/MAPK/Ras_B-Raf/thr /kinetics/MAPK/MEK_P REAC sA B addmsg /kinetics/MAPK/Ras_C-Raf/ser /kinetics/MAPK/MEK_P MM_PRD pA addmsg /kinetics/MAPK/Ras_C-Raf/thr /kinetics/MAPK/MEK_P REAC sA B addmsg /kinetics/MAPK/PP2A/dephosSer /kinetics/MAPK/MEK_P REAC sA B addmsg /kinetics/MAPK/PP2A/dephosThr /kinetics/MAPK/MEK_P MM_PRD pA addmsg /kinetics/MAPK/Rap1_B-Raf/ser /kinetics/MAPK/MEK_P MM_PRD pA addmsg /kinetics/MAPK/Rap1_B-Raf/thr /kinetics/MAPK/MEK_P REAC sA B addmsg /kinetics/U0126_group/U0126_bind_MEK_P /kinetics/MAPK/MEK_P REAC A B addmsg /kinetics/MAPK/kreac[8] /kinetics/MAPK/MEK_P REAC A B addmsg /kinetics/MAPK/Ras_B-Raf/thr /kinetics/MAPK/MEK_PP MM_PRD pA addmsg /kinetics/MAPK/Ras_C-Raf/thr /kinetics/MAPK/MEK_PP MM_PRD pA addmsg /kinetics/MAPK/PP2A/dephosThr /kinetics/MAPK/MEK_PP REAC sA B addmsg /kinetics/MAPK/Rap1_B-Raf/thr /kinetics/MAPK/MEK_PP MM_PRD pA addmsg /kinetics/U0126_group/U0126_bind_MEK_PP /kinetics/MAPK/MEK_PP REAC A B addmsg /kinetics/MAPK/kreac /kinetics/MAPK/MEK_PP REAC A B addmsg /kinetics/MAPK/ppMEK_act_Erk2 /kinetics/MAPK/MEK_PP REAC B A addmsg /kinetics/MAPK/MEK_PP.Erk2 /kinetics/MAPK/ppMEK_act_Erk2 SUBSTRATE n addmsg /kinetics/MAPK/MEK_PP /kinetics/MAPK/ppMEK_act_Erk2 PRODUCT n addmsg /kinetics/MAPK/ERK2-PP /kinetics/MAPK/ppMEK_act_Erk2 PRODUCT n addmsg /kinetics/MAPK/kreac /kinetics/MAPK/ERK2 REAC A B addmsg /kinetics/MAPK/kreac[8] /kinetics/MAPK/ERK2 REAC A B addmsg /kinetics/MAPK/kreac[2] /kinetics/MAPK/ERK2 REAC A B addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph /kinetics/MAPK/ERK2 MM_PRD pA addmsg /kinetics/U0126_group/kreac[1] /kinetics/MAPK/ERK2 REAC A B addmsg /kinetics/U0126_group/kreac[4] /kinetics/MAPK/ERK2 REAC A B addmsg /kinetics/U0126_group/kreac[9] /kinetics/MAPK/ERK2 REAC A B addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph_dppErk /kinetics/MAPK/ERK2 MM_PRD pA addmsg /kinetics/MAPK/ppErk_dimerize /kinetics/MAPK/ERK2-PP REAC A B addmsg /kinetics/MAPK/ppErk_dimerize /kinetics/MAPK/ERK2-PP REAC A B addmsg /kinetics/MAPK/ppMEK_act_Erk2 /kinetics/MAPK/ERK2-PP REAC B A addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph /kinetics/MAPK/ERK2-PP REAC sA B addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph_dppErk /kinetics/MAPK/ERK2-PP MM_PRD pA addmsg /kinetics/MAPK/ERK2 /kinetics/MAPK/kreac SUBSTRATE n addmsg /kinetics/MAPK/MEK_PP.Erk2 /kinetics/MAPK/kreac PRODUCT n addmsg /kinetics/MAPK/MEK_PP /kinetics/MAPK/kreac SUBSTRATE n addmsg /kinetics/MAPK/ERK2 /kinetics/MAPK/kreac[2] SUBSTRATE n addmsg /kinetics/MAPK/MEK /kinetics/MAPK/kreac[2] SUBSTRATE n addmsg /kinetics/MAPK/MEK.Erk2 /kinetics/MAPK/kreac[2] PRODUCT n addmsg /kinetics/MAPK/ERK2 /kinetics/MAPK/kreac[8] SUBSTRATE n addmsg /kinetics/MAPK/MEK_P /kinetics/MAPK/kreac[8] SUBSTRATE n addmsg /kinetics/MAPK/MEK_P.Erk2 /kinetics/MAPK/kreac[8] PRODUCT n addmsg /kinetics/MAPK/dppErk2_cytosol /kinetics/MAPK/ppErk_dimerize PRODUCT n addmsg /kinetics/MAPK/ERK2-PP /kinetics/MAPK/ppErk_dimerize SUBSTRATE n addmsg /kinetics/MAPK/ERK2-PP /kinetics/MAPK/ppErk_dimerize SUBSTRATE n addmsg /kinetics/MAPK/ppErk_dimerize /kinetics/MAPK/dppErk2_cytosol REAC B A addmsg /kinetics/MAPK/dppErk2_cytosol/kenz /kinetics/MAPK/dppErk2_cytosol REAC eA B addmsg /kinetics/MAPK/dppErk2_cytosol/kenz[1] /kinetics/MAPK/dppErk2_cytosol REAC eA B addmsg /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph_dppErk /kinetics/MAPK/dppErk2_cytosol REAC sA B addmsg /kinetics/MAPK/dppErk2_cytosol/kenz[2] /kinetics/MAPK/dppErk2_cytosol REAC eA B addmsg /kinetics/MAPK/dppErk2_cytosol /kinetics/MAPK/dppErk2_cytosol/kenz ENZYME n addmsg /kinetics/Sos_Grb2/Sos.Grb2 /kinetics/MAPK/dppErk2_cytosol/kenz SUBSTRATE n addmsg /kinetics/MAPK/dppErk2_cytosol /kinetics/MAPK/dppErk2_cytosol/kenz[1] ENZYME n addmsg /kinetics/Sos_Grb2/Sos /kinetics/MAPK/dppErk2_cytosol/kenz[1] SUBSTRATE n addmsg /kinetics/MAPK/dppErk2_cytosol /kinetics/MAPK/dppErk2_cytosol/kenz[2] ENZYME n addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/MAPK/dppErk2_cytosol/kenz[2] SUBSTRATE n addmsg /kinetics/MAPK/PP2A/dephosSer /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A/dephosThr /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A/dephosSer[1] /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A/dephosThr[1] /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A/dephosThr_ppMEK.Erk2 /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A/dephosSer_pMEK.Erk2 /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A/dephosSer[2] /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A/dephosThr[2] /kinetics/MAPK/PP2A REAC eA B addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/dephosSer ENZYME n addmsg /kinetics/MAPK/MEK_P /kinetics/MAPK/PP2A/dephosSer SUBSTRATE n addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/dephosThr ENZYME n addmsg /kinetics/MAPK/MEK_PP /kinetics/MAPK/PP2A/dephosThr SUBSTRATE n addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/dephosSer[1] ENZYME n addmsg /kinetics/U0126_group/U0126.MEK_P /kinetics/MAPK/PP2A/dephosSer[1] SUBSTRATE n addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/dephosThr[1] ENZYME n addmsg /kinetics/U0126_group/U0126.MEK_PP /kinetics/MAPK/PP2A/dephosThr[1] SUBSTRATE n addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/dephosSer_pMEK.Erk2 ENZYME n addmsg /kinetics/MAPK/MEK_P.Erk2 /kinetics/MAPK/PP2A/dephosSer_pMEK.Erk2 SUBSTRATE n addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/dephosThr_ppMEK.Erk2 ENZYME n addmsg /kinetics/MAPK/MEK_PP.Erk2 /kinetics/MAPK/PP2A/dephosThr_ppMEK.Erk2 SUBSTRATE n addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/dephosSer[2] ENZYME n addmsg /kinetics/U0126_group/U0126.pMEK.Erk2 /kinetics/MAPK/PP2A/dephosSer[2] SUBSTRATE n addmsg /kinetics/MAPK/PP2A /kinetics/MAPK/PP2A/dephosThr[2] ENZYME n addmsg /kinetics/U0126_group/U0126.ppMEK.Erk2 /kinetics/MAPK/PP2A/dephosThr[2] SUBSTRATE n addmsg /kinetics/MAPK/Ras_bind_B-Raf /kinetics/MAPK/B-Raf REAC A B addmsg /kinetics/Ras_GAP*/kenz2 /kinetics/MAPK/B-Raf MM_PRD pA addmsg /kinetics/MAPK/Rap1_bind_B-Raf /kinetics/MAPK/B-Raf REAC A B addmsg /kinetics/Rap1_GAP/kenz2 /kinetics/MAPK/B-Raf MM_PRD pA addmsg /kinetics/Ras_GAP*/kenz /kinetics/MAPK/Ras-GTP REAC sA B addmsg /kinetics/MAPK/Ras_bind_B-Raf /kinetics/MAPK/Ras-GTP REAC A B addmsg /kinetics/MAPK/Ras_bind_C-Raf /kinetics/MAPK/Ras-GTP REAC A B addmsg /kinetics/Ras_GTPase /kinetics/MAPK/Ras-GTP REAC A B addmsg /kinetics/TrkA/pTrkA_g/pTrkA.pShc.Sos.Grb2/TrkA.Shc.Grb2.Sos_act /kinetics/MAPK/Ras-GTP MM_PRD pA addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR/pEGFR_act /kinetics/MAPK/Ras-GTP MM_PRD pA addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl/pEGFR.c-Cbl_act /kinetics/MAPK/Ras-GTP MM_PRD pA addmsg /kinetics/MAPK/Ras_bind_C-Raf /kinetics/MAPK/C-Raf REAC A B addmsg /kinetics/Ras_GAP*/kenz3 /kinetics/MAPK/C-Raf MM_PRD pA addmsg /kinetics/MAPK/Rap1_bind_B-Raf /kinetics/MAPK/Rap1_B-Raf REAC B A addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser[1] /kinetics/MAPK/Rap1_B-Raf REAC eA B addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr[1] /kinetics/MAPK/Rap1_B-Raf REAC eA B addmsg /kinetics/MAPK/Rap1_B-Raf/ser /kinetics/MAPK/Rap1_B-Raf REAC eA B addmsg /kinetics/MAPK/Rap1_B-Raf/thr /kinetics/MAPK/Rap1_B-Raf REAC eA B addmsg /kinetics/MAPK/Rap1_B-Raf/ser[1] /kinetics/MAPK/Rap1_B-Raf REAC eA B addmsg /kinetics/MAPK/Rap1_B-Raf/thr[1] /kinetics/MAPK/Rap1_B-Raf REAC eA B addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser /kinetics/MAPK/Rap1_B-Raf REAC eA B addmsg /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr /kinetics/MAPK/Rap1_B-Raf REAC eA B addmsg /kinetics/Rap1_GAP/kenz2 /kinetics/MAPK/Rap1_B-Raf REAC sA B addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/MAPK/Rap1_B-Raf/ser ENZYME n addmsg /kinetics/MAPK/MEK /kinetics/MAPK/Rap1_B-Raf/ser SUBSTRATE n addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/MAPK/Rap1_B-Raf/thr ENZYME n addmsg /kinetics/MAPK/MEK_P /kinetics/MAPK/Rap1_B-Raf/thr SUBSTRATE n addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser ENZYME n addmsg /kinetics/U0126_group/U0126.MEK /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser SUBSTRATE n addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr ENZYME n addmsg /kinetics/U0126_group/U0126.MEK_P /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr SUBSTRATE n addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/MAPK/Rap1_B-Raf/ser[1] ENZYME n addmsg /kinetics/MAPK/MEK.Erk2 /kinetics/MAPK/Rap1_B-Raf/ser[1] SUBSTRATE n addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/MAPK/Rap1_B-Raf/thr[1] ENZYME n addmsg /kinetics/MAPK/MEK_P.Erk2 /kinetics/MAPK/Rap1_B-Raf/thr[1] SUBSTRATE n addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser[1] ENZYME n addmsg /kinetics/U0126_group/U0126.MEK.Erk2 /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser[1] SUBSTRATE n addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr[1] ENZYME n addmsg /kinetics/U0126_group/U0126.pMEK.Erk2 /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_thr[1] SUBSTRATE n addmsg /kinetics/MAPK/Ras_bind_B-Raf /kinetics/MAPK/Ras_B-Raf REAC B A addmsg /kinetics/Ras_GAP*/kenz2 /kinetics/MAPK/Ras_B-Raf REAC sA B addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser[1] /kinetics/MAPK/Ras_B-Raf REAC eA B addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr[1] /kinetics/MAPK/Ras_B-Raf REAC eA B addmsg /kinetics/MAPK/Ras_B-Raf/ser /kinetics/MAPK/Ras_B-Raf REAC eA B addmsg /kinetics/MAPK/Ras_B-Raf/thr /kinetics/MAPK/Ras_B-Raf REAC eA B addmsg /kinetics/MAPK/Ras_B-Raf/ser[1] /kinetics/MAPK/Ras_B-Raf REAC eA B addmsg /kinetics/MAPK/Ras_B-Raf/thr[1] /kinetics/MAPK/Ras_B-Raf REAC eA B addmsg /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr /kinetics/MAPK/Ras_B-Raf REAC eA B addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/MAPK/Ras_B-Raf/ser ENZYME n addmsg /kinetics/MAPK/MEK /kinetics/MAPK/Ras_B-Raf/ser SUBSTRATE n addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/MAPK/Ras_B-Raf/thr ENZYME n addmsg /kinetics/MAPK/MEK_P /kinetics/MAPK/Ras_B-Raf/thr SUBSTRATE n addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser ENZYME n addmsg /kinetics/U0126_group/U0126.MEK /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser SUBSTRATE n addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr ENZYME n addmsg /kinetics/U0126_group/U0126.MEK_P /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr SUBSTRATE n addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/MAPK/Ras_B-Raf/ser[1] ENZYME n addmsg /kinetics/MAPK/MEK.Erk2 /kinetics/MAPK/Ras_B-Raf/ser[1] SUBSTRATE n addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/MAPK/Ras_B-Raf/thr[1] ENZYME n addmsg /kinetics/MAPK/MEK_P.Erk2 /kinetics/MAPK/Ras_B-Raf/thr[1] SUBSTRATE n addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser[1] ENZYME n addmsg /kinetics/U0126_group/U0126.MEK.Erk2 /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser[1] SUBSTRATE n addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr[1] ENZYME n addmsg /kinetics/U0126_group/U0126.pMEK.Erk2 /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_thr[1] SUBSTRATE n addmsg /kinetics/MAPK/Ras_bind_C-Raf /kinetics/MAPK/Ras_C-Raf REAC B A addmsg /kinetics/Ras_GAP*/kenz3 /kinetics/MAPK/Ras_C-Raf REAC sA B addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser[1] /kinetics/MAPK/Ras_C-Raf REAC eA B addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr[1] /kinetics/MAPK/Ras_C-Raf REAC eA B addmsg /kinetics/MAPK/Ras_C-Raf/ser /kinetics/MAPK/Ras_C-Raf REAC eA B addmsg /kinetics/MAPK/Ras_C-Raf/thr /kinetics/MAPK/Ras_C-Raf REAC eA B addmsg /kinetics/MAPK/Ras_C-Raf/ser[1] /kinetics/MAPK/Ras_C-Raf REAC eA B addmsg /kinetics/MAPK/Ras_C-Raf/thr[1] /kinetics/MAPK/Ras_C-Raf REAC eA B addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr /kinetics/MAPK/Ras_C-Raf REAC eA B addmsg /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser /kinetics/MAPK/Ras_C-Raf REAC eA B addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/MAPK/Ras_C-Raf/ser ENZYME n addmsg /kinetics/MAPK/MEK /kinetics/MAPK/Ras_C-Raf/ser SUBSTRATE n addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/MAPK/Ras_C-Raf/thr ENZYME n addmsg /kinetics/MAPK/MEK_P /kinetics/MAPK/Ras_C-Raf/thr SUBSTRATE n addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr ENZYME n addmsg /kinetics/U0126_group/U0126.MEK_P /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr SUBSTRATE n addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser ENZYME n addmsg /kinetics/U0126_group/U0126.MEK /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser SUBSTRATE n addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/MAPK/Ras_C-Raf/thr[1] ENZYME n addmsg /kinetics/MAPK/MEK_P.Erk2 /kinetics/MAPK/Ras_C-Raf/thr[1] SUBSTRATE n addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/MAPK/Ras_C-Raf/ser[1] ENZYME n addmsg /kinetics/MAPK/MEK.Erk2 /kinetics/MAPK/Ras_C-Raf/ser[1] SUBSTRATE n addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser[1] ENZYME n addmsg /kinetics/U0126_group/U0126.MEK.Erk2 /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser[1] SUBSTRATE n addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr[1] ENZYME n addmsg /kinetics/U0126_group/U0126.pMEK.Erk2 /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr[1] SUBSTRATE n addmsg /kinetics/MAPK/B-Raf /kinetics/MAPK/Ras_bind_B-Raf SUBSTRATE n addmsg /kinetics/MAPK/Ras-GTP /kinetics/MAPK/Ras_bind_B-Raf SUBSTRATE n addmsg /kinetics/MAPK/Ras_B-Raf /kinetics/MAPK/Ras_bind_B-Raf PRODUCT n addmsg /kinetics/MAPK/B-Raf /kinetics/MAPK/Rap1_bind_B-Raf SUBSTRATE n addmsg /kinetics/MAPK/Rap1_B-Raf /kinetics/MAPK/Rap1_bind_B-Raf PRODUCT n addmsg /kinetics/TrkA/Rap1GTP /kinetics/MAPK/Rap1_bind_B-Raf SUBSTRATE n addmsg /kinetics/MAPK/Ras-GTP /kinetics/MAPK/Ras_bind_C-Raf SUBSTRATE n addmsg /kinetics/MAPK/C-Raf /kinetics/MAPK/Ras_bind_C-Raf SUBSTRATE n addmsg /kinetics/MAPK/Ras_C-Raf /kinetics/MAPK/Ras_bind_C-Raf PRODUCT n addmsg /kinetics/Dok-RasGAP/Dok2 /kinetics/Dok-RasGAP/dephospho_ppDok2 PRODUCT n addmsg /kinetics/Dok-RasGAP/pDok2 /kinetics/Dok-RasGAP/dephospho_ppDok2 SUBSTRATE n addmsg /kinetics/Dok-RasGAP/dephospho_ppDok2 /kinetics/Dok-RasGAP/Dok2 REAC B A addmsg /kinetics/EGFR_g/probe/non-ubiqEGFR*_total/EGFR_act_Dok2 /kinetics/Dok-RasGAP/Dok2 REAC sA B addmsg /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr/TrkA_act_Dok /kinetics/Dok-RasGAP/Dok2 REAC sA B addmsg /kinetics/Ras_GAP /kinetics/Dok-RasGAP/ppDok2_bind_RasGAP SUBSTRATE n addmsg /kinetics/Ras_GAP* /kinetics/Dok-RasGAP/ppDok2_bind_RasGAP PRODUCT n addmsg /kinetics/Dok-RasGAP/pDok2 /kinetics/Dok-RasGAP/ppDok2_bind_RasGAP SUBSTRATE n addmsg /kinetics/Dok-RasGAP/dephospho_ppDok2 /kinetics/Dok-RasGAP/pDok2 REAC A B addmsg /kinetics/Dok-RasGAP/ppDok2_bind_RasGAP /kinetics/Dok-RasGAP/pDok2 REAC A B addmsg /kinetics/EGFR_g/probe/non-ubiqEGFR*_total/EGFR_act_Dok2 /kinetics/Dok-RasGAP/pDok2 MM_PRD pA addmsg /kinetics/TrkA/pTrkA_g/probe/pTrkA_membr/TrkA_act_Dok /kinetics/Dok-RasGAP/pDok2 MM_PRD pA addmsg /kinetics/Dok-RasGAP/pDok2 /kinetics/ppDoc2_total SUMTOTAL n nInit addmsg /kinetics/Ras_GAP* /kinetics/ppDoc2_total SUMTOTAL n nInit addmsg /kinetics/TrkA/dephospho_FRS2 /kinetics/FRS2_g/FRS2 REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/FRS2_bind_EGFR /kinetics/FRS2_g/FRS2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/FRS2_bind_pTrkA /kinetics/FRS2_g/FRS2 REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/FRS2_bind_pTrkA[1] /kinetics/FRS2_g/FRS2 REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_EGFR /kinetics/FRS2_g/FRS2 REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_EGFR[1] /kinetics/FRS2_g/FRS2 REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[6] /kinetics/FRS2_g/FRS2 REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[4] /kinetics/FRS2_g/FRS2 REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[2] /kinetics/FRS2_g/FRS2 REAC B A addmsg /kinetics/TrkA/dephospho_FRS2 /kinetics/FRS2_g/pFRS2 REAC A B addmsg /kinetics/TrkA/pTrkA_g/pFRS2_bind_pTrkA /kinetics/FRS2_g/pFRS2 REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2_bind_EGFR /kinetics/FRS2_g/pFRS2 REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/pFRS2_bind_pTrkA[1] /kinetics/FRS2_g/pFRS2 REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2_bind_EGFR /kinetics/FRS2_g/pFRS2 REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[1] /kinetics/FRS2_g/pFRS2 REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2_bind_EGFR[1] /kinetics/FRS2_g/pFRS2 REAC A B addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[1] /kinetics/FRS2_g/pFRS2 REAC B A addmsg /kinetics/TrkA/pTrkA_endo_g/dephosphorylation3[3] /kinetics/FRS2_g/pFRS2 REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[4] /kinetics/FRS2_g/pFRS2 REAC B A addmsg /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[6] /kinetics/FRS2_g/pFRS2 REAC B A addmsg /kinetics/TrkA/pTrkA_g/pTrkA.FRS2 /kinetics/FRS2_g/probe/FRS2_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.FRS2_endo /kinetics/FRS2_g/probe/FRS2_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/FRS2.pEGFR /kinetics/FRS2_g/probe/FRS2_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2.pEGFR.c-Cbl /kinetics/FRS2_g/probe/FRS2_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2.pEGFR.c-Cbl.ubiq /kinetics/FRS2_g/probe/FRS2_total SUMTOTAL n nInit addmsg /kinetics/FRS2_g/FRS2 /kinetics/FRS2_g/probe/FRS2_total SUMTOTAL n nInit addmsg /kinetics/FRS2_g/probe/pFRS2_total /kinetics/FRS2_g/probe/FRS2_total SUMTOTAL n nInit addmsg /kinetics/FRS2_g/pFRS2 /kinetics/FRS2_g/probe/pFRS2_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pFRS2_total /kinetics/FRS2_g/probe/pFRS2_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/probe/pEGFR.pFRS2_total /kinetics/FRS2_g/probe/pFRS2_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/activate_EGFR /kinetics/EGFR_g/EGFR REAC A B addmsg /kinetics/EGFR_g/EGFR_synthesis /kinetics/EGFR_g/EGFR REAC B A addmsg /kinetics/EGFR_g/EGFR /kinetics/EGFR_g/activate_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/L.EGFR /kinetics/EGFR_g/activate_EGFR PRODUCT n addmsg /kinetics/EGFR_g/EGF /kinetics/EGFR_g/activate_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/activate_EGFR /kinetics/EGFR_g/EGF REAC A B addmsg /kinetics/EGF_stim/stim_EGF_5ng /kinetics/EGFR_g/EGF SLAVE output addmsg /kinetics/EGFR_g/activate_EGFR /kinetics/EGFR_g/L.EGFR REAC B A addmsg /kinetics/EGFR_g/dimerize_EGFR /kinetics/EGFR_g/L.EGFR REAC A B addmsg /kinetics/EGFR_g/dimerize_EGFR /kinetics/EGFR_g/L.EGFR REAC A B addmsg /kinetics/EGFR_g/L.EGFR /kinetics/EGFR_g/dimerize_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/L.EGFR /kinetics/EGFR_g/dimerize_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/L.EGFR_dimer /kinetics/EGFR_g/dimerize_EGFR PRODUCT n addmsg /kinetics/EGFR_g/L.EGFR_dimer /kinetics/EGFR_g/Tyr_phosphory SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/L.dpEGFR /kinetics/EGFR_g/Tyr_phosphory PRODUCT n addmsg /kinetics/EGFR_g/Tyr_phosphory /kinetics/EGFR_g/L.EGFR_dimer REAC A B addmsg /kinetics/EGFR_g/dimerize_EGFR /kinetics/EGFR_g/L.EGFR_dimer REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/EGFR_ubiq_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/EGFR_ubiq_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/EGFR_ubiq_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.Crk.C3G.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/EGFR_ubiq_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/Shc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/EGFR_ubiq_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/EGFR_ubiq_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[6] /kinetics/EGFR_g/probe/EGFR_ubiq_total REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/EGFR_ubiq_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/L.dpEGFR /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc.pEGFR.c-Cbl /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/Shc.ppEGFR /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/pShc.pEGFR /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/probe/effective_C3G_total /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2.pEGFR.c-Cbl /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/FRS2.pEGFR /kinetics/EGFR_g/probe/non-ubiqEGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/probe/non-ubiqEGFR*_total /kinetics/EGFR_g/probe/non-ubiqEGFR*_total/EGFR_act_Dok2 ENZYME n addmsg /kinetics/Dok-RasGAP/Dok2 /kinetics/EGFR_g/probe/non-ubiqEGFR*_total/EGFR_act_Dok2 SUBSTRATE n addmsg /kinetics/EGFR_g/probe/non-ubiqEGFR*_total /kinetics/EGFR_g/probe/EGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/probe/EGFR_ubiq_total /kinetics/EGFR_g/probe/EGFR*_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR /kinetics/EGFR_g/probe/pEGFR.pFRS2_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl /kinetics/EGFR_g/probe/pEGFR.pFRS2_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/pEGFR.pFRS2_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.Crk.C3G.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/pEGFR.pFRS2_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/probe/effective_C3G_total /kinetics/EGFR_g/probe/pEGFR.pFRS2_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl /kinetics/EGFR_g/probe/effective_C3G_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR /kinetics/EGFR_g/probe/effective_C3G_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/pShc.pEGFR /kinetics/EGFR_g/probe/pShc.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR /kinetics/EGFR_g/probe/pShc.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl /kinetics/EGFR_g/probe/pShc.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl /kinetics/EGFR_g/probe/pShc.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/pShc.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/pShc.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/Shc.ppEGFR /kinetics/EGFR_g/probe/non-pShc.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc.pEGFR.c-Cbl /kinetics/EGFR_g/probe/non-pShc.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/Shc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/probe/non-pShc.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR /kinetics/EGFR_g/probe/Sos.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl /kinetics/EGFR_g/probe/Sos.pEGFR_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/EGFR_synthesis /kinetics/EGFR_g/proto_EGFR REAC A B addmsg /kinetics/EGFR_g/proto_EGFR /kinetics/EGFR_g/EGFR_synthesis SUBSTRATE n addmsg /kinetics/EGFR_g/EGFR /kinetics/EGFR_g/EGFR_synthesis PRODUCT n addmsg /kinetics/EGFR_g/pEGFR_g/Shc_bind_EGFR /kinetics/EGFR_g/pEGFR_g/Shc.ppEGFR REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/Shc_phosphory[1] /kinetics/EGFR_g/pEGFR_g/Shc.ppEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[6] /kinetics/EGFR_g/pEGFR_g/Shc.ppEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/Shc_phosphory[1] /kinetics/EGFR_g/pEGFR_g/pShc.pEGFR REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/pShc_bind_EGFR /kinetics/EGFR_g/pEGFR_g/pShc.pEGFR REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/pShc_bind_Sos.Grb2[1] /kinetics/EGFR_g/pEGFR_g/pShc.pEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[3] /kinetics/EGFR_g/pEGFR_g/pShc.pEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Grb2_bind_EGFR[1] /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[4] /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/pShc_bind_Sos.Grb2[1] /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR/pEGFR_act ENZYME n addmsg /kinetics/Ras-GDP /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR/pEGFR_act SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/Shc_bind_EGFR /kinetics/EGFR_g/pEGFR_g/L.dpEGFR REAC A B addmsg /kinetics/EGFR_g/Tyr_phosphory /kinetics/EGFR_g/pEGFR_g/L.dpEGFR REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Grb2_bind_EGFR[1] /kinetics/EGFR_g/pEGFR_g/L.dpEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl /kinetics/EGFR_g/pEGFR_g/L.dpEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/pShc_bind_EGFR /kinetics/EGFR_g/pEGFR_g/L.dpEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/FRS2_bind_EGFR /kinetics/EGFR_g/pEGFR_g/L.dpEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2_bind_EGFR /kinetics/EGFR_g/pEGFR_g/L.dpEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/FRS2.pEGFR /kinetics/EGFR_g/pEGFR_g/FRS2_Tyr_phosphory SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR /kinetics/EGFR_g/pEGFR_g/FRS2_Tyr_phosphory PRODUCT n addmsg /kinetics/EGFR_g/pEGFR_g/Shc.ppEGFR /kinetics/EGFR_g/pEGFR_g/Shc_phosphory[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pShc.pEGFR /kinetics/EGFR_g/pEGFR_g/Shc_phosphory[1] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR_g/FRS2_bind_EGFR /kinetics/EGFR_g/pEGFR_g/FRS2.pEGFR REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/FRS2_Tyr_phosphory /kinetics/EGFR_g/pEGFR_g/FRS2.pEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[5] /kinetics/EGFR_g/pEGFR_g/FRS2.pEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2_bind_EGFR /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/FRS2_Tyr_phosphory /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/FRS2_bind_Crk /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[2] /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[1] /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR REAC A B addmsg /kinetics/EGFR_g/pEGFR_g/FRS2_bind_Crk /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR REAC B A addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR/EGFR-C3G_act ENZYME n addmsg /kinetics/Rap1.GDP /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR/EGFR-C3G_act SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/L.dpEGFR /kinetics/EGFR_g/pEGFR_g/FRS2_bind_EGFR SUBSTRATE n addmsg /kinetics/FRS2_g/FRS2 /kinetics/EGFR_g/pEGFR_g/FRS2_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/FRS2.pEGFR /kinetics/EGFR_g/pEGFR_g/FRS2_bind_EGFR PRODUCT n addmsg /kinetics/EGFR_g/pEGFR_g/L.dpEGFR /kinetics/EGFR_g/pEGFR_g/Shc_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/Shc.ppEGFR /kinetics/EGFR_g/pEGFR_g/Shc_bind_EGFR PRODUCT n addmsg /kinetics/SHC/Shc /kinetics/EGFR_g/pEGFR_g/Shc_bind_EGFR SUBSTRATE n addmsg /kinetics/SHC/pShc /kinetics/EGFR_g/pEGFR_g/pShc_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/L.dpEGFR /kinetics/EGFR_g/pEGFR_g/pShc_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pShc.pEGFR /kinetics/EGFR_g/pEGFR_g/pShc_bind_EGFR PRODUCT n addmsg /kinetics/EGFR_g/pEGFR_g/L.dpEGFR /kinetics/EGFR_g/pEGFR_g/pShc.Grb2_bind_EGFR[1] SUBSTRATE n addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/EGFR_g/pEGFR_g/pShc.Grb2_bind_EGFR[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR /kinetics/EGFR_g/pEGFR_g/pShc.Grb2_bind_EGFR[1] PRODUCT n addmsg /kinetics/FRS2_g/pFRS2 /kinetics/EGFR_g/pEGFR_g/pFRS2_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR /kinetics/EGFR_g/pEGFR_g/pFRS2_bind_EGFR PRODUCT n addmsg /kinetics/EGFR_g/pEGFR_g/L.dpEGFR /kinetics/EGFR_g/pEGFR_g/pFRS2_bind_EGFR SUBSTRATE n addmsg /kinetics/Sos_Grb2/Sos.Grb2 /kinetics/EGFR_g/pEGFR_g/pShc_bind_Sos.Grb2[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR /kinetics/EGFR_g/pEGFR_g/pShc_bind_Sos.Grb2[1] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR_g/pShc.pEGFR /kinetics/EGFR_g/pEGFR_g/pShc_bind_Sos.Grb2[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR /kinetics/EGFR_g/pEGFR_g/FRS2_bind_Crk SUBSTRATE n addmsg /kinetics/TrkA/Crk.C3G /kinetics/EGFR_g/pEGFR_g/FRS2_bind_Crk SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR /kinetics/EGFR_g/pEGFR_g/FRS2_bind_Crk PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_bind_EGFR[1] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[2] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR[3] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2_bind_EGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_EGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl REAC A B addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl PRODUCT n addmsg /kinetics/EGFR_g/pEGFR_g/L.dpEGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl SUBSTRATE n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[1] PRODUCT n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[4] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pShc.Sos.Grb2.pEGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[4] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[4] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_bind_EGFR[1] /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_phosphory[2] /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc.pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[6] /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[4] /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc.pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_phosphory[2] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[3] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_Sos.Grb2[2] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR[3] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[3] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[4] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[5] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_Sos.Grb2[2] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl/pEGFR.c-Cbl_act ENZYME n addmsg /kinetics/Ras-GDP /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl/pEGFR.c-Cbl_act SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[1] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_Crk[1] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl/EGFR.C3G.c-Cbl_act ENZYME n addmsg /kinetics/Rap1.GDP /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl/EGFR.C3G.c-Cbl_act SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_phosphory[2] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_phosphory[2] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_Tyr_phosphory[1] /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2.pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_EGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[5] /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[6] /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2.pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_Tyr_phosphory[1] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_Crk[1] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2_bind_EGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[2] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[1] /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_Tyr_phosphory[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_Tyr_phosphory[1] PRODUCT n addmsg /kinetics/TrkA/Crk.C3G /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_Crk[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_Crk[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_Crk[1] PRODUCT n addmsg /kinetics/FRS2_g/pFRS2 /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2_bind_EGFR PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.pEGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[2] SUBSTRATE n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[2] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[2] PRODUCT n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[3] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/pShc.pEGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[3] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[3] PRODUCT n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[5] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/FRS2.pEGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[5] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[5] PRODUCT n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[6] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR_g/Shc.ppEGFR /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[6] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[6] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_bind_EGFR[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_bind_EGFR[1] PRODUCT n addmsg /kinetics/SHC/Shc /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_bind_EGFR[1] SUBSTRATE n addmsg /kinetics/SHC/pShc /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR[3] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR[3] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR[3] PRODUCT n addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR PRODUCT n addmsg /kinetics/FRS2_g/FRS2 /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_EGFR PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_EGFR SUBSTRATE n addmsg /kinetics/Sos_Grb2/Sos.Grb2 /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_Sos.Grb2[2] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_Sos.Grb2[2] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_Sos.Grb2[2] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[2] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[2] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[3] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[3] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[5] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[5] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[2] /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[2] /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Grb2_bind_EGFR /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_EGFR /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/Shc_bind_EGFR /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_EGFR[1] /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2_bind_EGFR[1] /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[3] /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[3] /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_Sos.Grb2[3] /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_EGFR /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.Crk.C3G.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[5] /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[5] /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Grb2_bind_EGFR /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_Sos.Grb2[3] /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.Crk.C3G.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation PRODUCT n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation PRODUCT n addmsg /kinetics/TrkA/Crk.C3G /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[5] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[5] PRODUCT n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[5] PRODUCT n addmsg /kinetics/Sos_Grb2/Sos.Grb2 /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[5] PRODUCT n addmsg /kinetics/SHC/pShc /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[5] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[3] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[3] PRODUCT n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[3] PRODUCT n addmsg /kinetics/SHC/pShc /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[3] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[2] SUBSTRATE n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[2] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[2] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[2] /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[3] /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[5] /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[1] /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[4] /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_Crk[1] /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[1] /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[1] /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2_bind_EGFR[1] /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.Crk.C3G.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.Crk.C3G.pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_Crk[1] /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.Crk.C3G.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/TrkA/Crk.C3G /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_Crk[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_Crk[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.Crk.C3G.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_Crk[1] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[1] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[1] PRODUCT n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[1] PRODUCT n addmsg /kinetics/FRS2_g/pFRS2 /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[1] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Grb2_bind_EGFR SUBSTRATE n addmsg /kinetics/SHC/pShc.Sos.Grb2 /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Grb2_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Grb2_bind_EGFR PRODUCT n addmsg /kinetics/SHC/Shc /kinetics/EGFR_g/pEGFR.ubiq_g/Shc_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/Shc_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/Shc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/Shc_bind_EGFR PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/Shc_bind_EGFR /kinetics/EGFR_g/pEGFR.ubiq_g/Shc.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[4] /kinetics/EGFR_g/pEGFR.ubiq_g/Shc.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[4] /kinetics/EGFR_g/pEGFR.ubiq_g/Shc.pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/SHC/pShc /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_EGFR SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_EGFR PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[4] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/Shc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[4] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/Shc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[4] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/proteosome /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[4] PRODUCT n addmsg /kinetics/SHC/Shc /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[4] PRODUCT n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[4] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[6] /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_EGFR[1] /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2.pEGFR.c-Cbl.ubiq REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[6] /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2.pEGFR.c-Cbl.ubiq REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2.pEGFR.c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[6] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[6] PRODUCT n addmsg /kinetics/FRS2_g/pFRS2 /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2_bind_EGFR[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2_bind_EGFR[1] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2_bind_EGFR[1] SUBSTRATE n addmsg /kinetics/FRS2_g/FRS2 /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_EGFR[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_EGFR[1] PRODUCT n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_EGFR[1] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_Sos.Grb2[3] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_Sos.Grb2[3] PRODUCT n addmsg /kinetics/Sos_Grb2/Sos.Grb2 /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_Sos.Grb2[3] SUBSTRATE n addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2.pEGFR.c-Cbl.ubiq /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[6] SUBSTRATE n addmsg /kinetics/EGFR_g/probe/EGFR_ubiq_total /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[6] PRODUCT n addmsg /kinetics/c-Cbl /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[6] PRODUCT n addmsg /kinetics/FRS2_g/FRS2 /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[6] PRODUCT n addmsg /kinetics/EGF_stim/stim_EGF_10ng[1] /kinetics/EGFR_g/EGF[2] SLAVE output addmsg /kinetics/EGFR_g/EGF[1] /kinetics/EGFR_g/EGF[3] SUMTOTAL n nInit addmsg /kinetics/EGFR_g/EGF[2] /kinetics/EGFR_g/EGF[3] SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl /kinetics/c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[2] /kinetics/c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[3] /kinetics/c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[4] /kinetics/c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[5] /kinetics/c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[1] /kinetics/c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation /kinetics/c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[2] /kinetics/c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[3] /kinetics/c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[1] /kinetics/c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[6] /kinetics/c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[5] /kinetics/c-Cbl REAC A B addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[6] /kinetics/c-Cbl REAC B A addmsg /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[4] /kinetics/c-Cbl REAC B A addmsg /kinetics/TrkA/NGF[3] /kinetics/kreac SUBSTRATE n addmsg /kinetics/TrkA/NGF[2] /kinetics/kreac SUBSTRATE n addmsg /kinetics/TrkA/NGF[1] /kinetics/kreac PRODUCT n addmsg /kinetics/effective_pEGFR.C3G_total /kinetics/effective_C3G_total SUMTOTAL n nInit addmsg /kinetics/effective_pTrkA.C3G_total /kinetics/effective_C3G_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl /kinetics/effective_pEGFR.C3G_total SUMTOTAL n nInit addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR /kinetics/effective_pEGFR.C3G_total SUMTOTAL n nInit addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo /kinetics/effective_pTrkA.C3G_total SUMTOTAL n nInit addmsg /kinetics/EGF_ramp/kreac[10] /kinetics/EGF_ramp/GATE REAC A B addmsg /kinetics/EGF_ramp/multiplier /kinetics/EGF_ramp/GATE SLAVE output addmsg /kinetics/EGF_ramp/kreac[10] /kinetics/EGF_ramp/EGF[2] REAC B A addmsg /kinetics/EGF_ramp/EGF_pulse /kinetics/EGF_ramp/kreac[10] SUBSTRATE n addmsg /kinetics/EGF_ramp/EGF[2] /kinetics/EGF_ramp/kreac[10] PRODUCT n addmsg /kinetics/EGF_ramp/GATE /kinetics/EGF_ramp/kreac[10] SUBSTRATE n addmsg /kinetics/EGF_ramp/kreac[10] /kinetics/EGF_ramp/EGF_pulse REAC A B addmsg /kinetics/EGF_ramp/stim_EGF_3ng /kinetics/EGF_ramp/EGF_pulse SLAVE output addmsg /kinetics/TrkA/GTPase /kinetics/Rap1.GDP REAC B A addmsg /kinetics/Rap1_GAP/kenz[1] /kinetics/Rap1.GDP MM_PRD pA addmsg /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl/EGFR.C3G.c-Cbl_act /kinetics/Rap1.GDP REAC sA B addmsg /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR/EGFR-C3G_act /kinetics/Rap1.GDP REAC sA B addmsg /kinetics/Rap1_GAP/kenz2 /kinetics/Rap1.GDP MM_PRD pA addmsg /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo/TrkA-C3G_act /kinetics/Rap1.GDP REAC sA B addmsg /kinetics/EGFR_g/probe/EGFR*_total /graphs/conc1/EGFR*_total.Co PLOT Co *EGFR*_total.Co *26 addmsg /kinetics/TrkA/pTrkA_total /graphs/conc1/pTrkA_total.Co PLOT Co *pTrkA_total.Co *43 addmsg /kinetics/Sos_Grb2/probe/pSos_total /graphs/conc1/Sos*_total.Co PLOT Co *Sos*_total.Co *0 addmsg /kinetics/MAPK/probe/Ras-GTP_total /graphs/conc1/Ras-GTP_total.Co PLOT Co *Ras-GTP_total.Co *62 addmsg /kinetics/MAPK/probe/Rap1-GTP_total /graphs/conc1/Rap1-GTP_total.Co PLOT Co *Rap1-GTP_total.Co *56 addmsg /kinetics/MAPK/probe/ERK2-PP_total /graphs/conc1/ERK2-PP_total.Co PLOT Co *ERK2-PP_total.Co *47 addmsg /kinetics/ppDoc2_total /graphs/conc1/ppDoc2_total.Co PLOT Co *ppDoc2_total.Co *orange addmsg /kinetics/MAPK/probe/ppMEK_total /graphs/conc1/ppMEK_total.Co PLOT Co *ppMEK_total.Co *31 addmsg /kinetics/Ras_GAP* /graphs/conc1/Ras_GAP*.Co PLOT Co *Ras_GAP*.Co *blue addmsg /kinetics/Sos_Grb2/probe/effect_Sos_total /graphs/conc1/effect_Sos_total.Co PLOT Co *effect_Sos_total.Co *brown addmsg /kinetics/effective_C3G_total /graphs/conc1/effective_C3G_total.Co PLOT Co *effective_C3G_total.Co *turquoise addmsg /kinetics/Rap1_GAP /graphs/conc1/Rap1_GAP.Co PLOT Co *Rap1_GAP.Co *blue addmsg /kinetics/EGFR_g/EGF /graphs/conc1/EGF.Co PLOT Co *EGF.Co *red addmsg /kinetics/TrkA/NGF /graphs/conc1/NGF.Co PLOT Co *NGF.Co *blue enddump // End of dump call /kinetics/Ras-GDP/notes LOAD \ "CoInit = 0.2uM from all117.g" \ "---" \ "CoInit = 0.1uM" \ "oza" call /kinetics/Rap1_GAP/notes LOAD \ "CoInit = 0.002 from all177.g" \ "" call /kinetics/Ras_GTPase/notes LOAD \ "JBC 263, pp18965-18971, 1988" \ "GTPase of Ras: 0.010/min." \ "" call /kinetics/Sos_Grb2/Grb2/notes LOAD \ "There is probably a lot of it in the cell: it is also known" \ "as Ash (abundant src homology protein I think). Also " \ "Waters et al JBC 271:30 18224 1996 say that only a small" \ "fraction of cellular Grb is precipitated out when SoS is" \ "precipitated. As most of the Sos seems to be associated" \ "with Grb2, it would seem like there is a lot of the latter." \ "Say 1 uM. I haven't been able to find a decent...." call /kinetics/Sos_Grb2/Sos/notes LOAD \ "CoInit = 0.1" \ "But Sos and Grb2 make constitutive complex," \ "remaings are in Sos.Grb2." \ "" call /kinetics/Sos_Grb2/dephosph_Sos/notes LOAD \ "kf = 0.1 -> 0.01" \ "oza" \ "---" \ "This dephosphorylation should be slower. Tau = 600" \ "" call /kinetics/Sos_Grb2/Grb2_bind_Sos*/notes LOAD \ "Same rates as Grb2_bind_Sos: Porfiri and McCormick JBC" \ "271:10 pp 5871 1996 show that the binding is not affected" \ "by the phosph." call /kinetics/Sos_Grb2/Grb2_bind_Sos/notes LOAD \ "As there are 2 SH3 domains, this reaction could be 2nd order." \ "I have a Kd of 22 uM from peptide binding (Lemmon et al " \ "JBC 269:50 pg 31653). However, Chook et al JBC 271:48 pg30472" \ "say it is 0.4uM with purified proteins, so we believe them." \ "They say it is 1:1 binding." call /kinetics/SHC/dephosph_Shc/notes LOAD \ "Time course of decline of phosph is 20 min. Part of this is" \ "the turnoff time of the EGFR itself. Lets assume a tau of" \ "10 min for this dephosph. It may be wildly off." \ "" call /kinetics/SHC/Shc/notes LOAD \ "There are 3 isoforms: 52 KDa and 46 KDa (See Okada et al" \ "JBC 270:35 pp 20737 1995). They are acted up on by the EGFR" \ "in very similar ways, and apparently both bind Grb2 similarly," \ "so we'll bundle them together here." \ "Sasaoka et al JBC 269:51 pp 32621 1994 show immunoprecs where" \ "it looks like there is at least as much Shc as Grb2. So" \ "we'll tentatively say there is 1 uM of Shc." \ "PTB domain " \ "---" \ "Effect of Shc-Sos complex activate Ras seems too much." \ "Let's decrease Shc conc. CoInit = 0.5uM" \ "" call /kinetics/SHC/pShc_bind_Sos.Grb2/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994, table on pg" \ "32623 indicates that this pathway accounts for about " \ "50% of the GEF activation. (88% - 39%). Error is large," \ "about 20%. Fig 1 is most useful in constraining rates." \ "" \ "Chook et al JBC 271:48 pp 30472, 1996 say that the Kd is" \ "0.2 uM for Shc binding to EGFR. The Kd for Grb direct binding" \ "is 0.7, so we'll ignore it." \ "---" \ "but existence of this pathway results persistent Ras activation " \ "even in the NGF stimulation." \ "I assume EGFR activation is necessary for the association of this complex." \ "oza" \ "kf = 0.5 -> 0, kb = 0.1 -> 0.1" \ "kf = 0, kb= 0.001666 (before mapk18c.g)" \ "Set Kd to 0.7uM. kf = 0.14286, kb = 0.1" \ "" call /kinetics/dephosph_Shc[1]/notes LOAD \ "Time course of decline of phosph is 20 min. Part of this is" \ "the turnoff time of the EGFR itself. Lets assume a tau of" \ "10 min for this dephosph. It may be wildly off." \ "---" \ "This is a copy of dephosph_Shc." \ "oza" call /kinetics/Ras_GAP*/notes LOAD \ "Here, Ras_GAP* means membrane localized RasGAP." \ "" call /kinetics/Ras_GAP*/kenz/notes LOAD \ "Vmax = 10, Km = 1" \ "" call /kinetics/Ras_GAP*/kenz3/notes LOAD \ "This Gap activity should be weaker than the activity against Ras-GTP alone." \ "Vmax = 2" \ "" call /kinetics/Ras_GAP/notes LOAD \ "CoInit = 0.002 from all177.g" \ "---" \ "RasGAP is known to distribute in cytosol in resting cell, and" \ "translocate to membrane upon EGF stimulation. The binding site " \ "of EGFR is unknown (RN.Jorissen et al., Exp Cell Res 284, 31-53," \ "2003) and C.Soler et al, JBC 268, 22010-22019, 1993 says that " \ "EGFR are not detectable in RasGAP immunoprecipitates from EGF " \ "treated cell lysate (Fig2A). " \ "CoInit = 0.3uM (assumption)" \ "" call /kinetics/NGF_ramp/notes LOAD \ "This group make a ramp stimulus." \ "" \ "Usage: " \ "Stim Level of stim_EGF should be set 3 times of final concentration required." \ "Kf of kreac should be set 1 / (3 * sloping period)." \ "Interpulse Delya of stim_off should be set (start time) + (sloping period)." \ "Baseline Level of multiplier can be used as a multiplier of concentration." \ "" \ "Ex. EGF increase to 1ng/ml in 5min after 100sec rest. " \ "stim_EGF: Stim Level = 0.1613nM," \ "stim_EGF: Interpulse Delay = 100sec," \ "multiplier: BaseLine = 1" \ "multiplier: Interpulse Delay = 100 + 5 * 60," \ "kreac: Kf = 1 / (3 * 5 * 60)." \ "" call /kinetics/NGF_ramp/GATE/notes LOAD \ "Mitogenic response occurs at about 2nM EGF according to fig" \ "in Lauffenburger and Linderman pg 257." call /kinetics/NGF_ramp/multiplier/notes LOAD \ "See note in EGF_ramp." call /kinetics/NGF_ramp/stim_NGF_3ng/notes LOAD \ "1ng/ml NGF = 0.038nM" \ "" call /kinetics/NGF_ramp/NGF_pulse/notes LOAD \ "Mitogenic response occurs at about 2nM EGF according to fig" \ "in Lauffenburger and Linderman pg 257." call /kinetics/NGF_ramp/NGF[2]/notes LOAD \ "Use SUMTOTAL(pool to pool) to give stim to EGF." \ "" call /kinetics/ubiquitine/notes LOAD \ "CoInit = 4uM assumption" \ "" call /kinetics/U0126_group/U0126.MEK.Erk2/notes LOAD \ "" \ "" call /kinetics/U0126_group/U0126.pMEK.Erk2/notes LOAD \ "" \ "" call /kinetics/U0126_group/U0126.ppMEK.Erk2/notes LOAD \ "" \ "" call /kinetics/U0126_group/kreac[1]/notes LOAD \ "k1 = 16.304" \ "k2 = 0.6" \ "based on the enzymatic reaction which ppMEK phosphorylate Erk." \ "---" \ "From Nishida et al., EMBO 20 pp466-479, 2001," \ "the docking site for MEK is located on the opposit side" call /kinetics/U0126_group/kreac[4]/notes LOAD \ "k1 = 16.304" \ "k2 = 0.6" \ "based on the enzymatic reaction which ppMEK phosphorylate Erk." \ "---" \ "From Nishida et al., EMBO 20 pp466-479, 2001," \ "the docking site for MEK is located on the opposit side" call /kinetics/U0126_group/kreac[9]/notes LOAD \ "k1 = 16.304" \ "k2 = 0.6" \ "based on the enzymatic reaction which ppMEK phosphorylate Erk." \ "---" \ "From Nishida et al., EMBO 20 pp466-479, 2001," \ "the docking site for MEK is located on the opposit side" call /kinetics/TrkA/GTPase/notes LOAD \ "JBC 263, pp18965-18971, 1988" \ "GTPase of smg p21 (Rap1): 0.007/min." \ "" call /kinetics/TrkA/Glycocyl_transferase/notes LOAD \ "start CoInt 0.001" call /kinetics/TrkA/degradation2/notes LOAD \ "JBC 277, pp38700-38708, 2002" \ "tau should be around 100min." \ "---" \ "See TrkA_synthesis too." call /kinetics/TrkA/TrkA_synthesis/notes LOAD \ "From JBC 277, pp38700-38708, 2002," \ "tau should be 20min." \ "" call /kinetics/TrkA/pro-TrkA/notes LOAD \ "JBC 277, pp38700-38709, 2002" \ "gp110-TrkA seems to exist around one-thirds of gp140-TrkA. Fig3A" call /kinetics/TrkA/p75/notes LOAD \ "44x10^3 low affinity sites/cell in PC12. So, nInit = 44000." \ "CoInit = 0.64839uM" \ "Mariano Barbacid et all, Cell, 65, 189-197, 1991" call /kinetics/TrkA/stim_NGF_100ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "" call /kinetics/TrkA/stim_NGF_10ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "" call /kinetics/TrkA/stim_NGF_1ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "" call /kinetics/TrkA/stim_NGF_1.5ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "" call /kinetics/TrkA/Crk_bind_C3G/notes LOAD \ "JBC 1994, vol269, pp32781-32787" \ "C3G binds to Crk SH3 domain with Kd of 2.8-27nM." \ "" call /kinetics/TrkA/stim_NGF_50ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "50ng/ml => 1.9nM" \ "" call /kinetics/TrkA/stim_NGF_5ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "50ng/ml => 1.9nM" \ "" call /kinetics/TrkA/stim_NGF_0.5ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "50ng/ml => 1.9nM" \ "" call /kinetics/TrkA/pTrkA_g/FRS2_Tyr_phosphory/notes LOAD \ "totaly assumption" \ "" call /kinetics/TrkA/pTrkA_g/Shc_Tyr_phosphory/notes LOAD \ "totaly assumption" \ "" call /kinetics/TrkA/pTrkA_g/FRS2_bind_pTrkA/notes LOAD \ "S.O.Meakin et.al., JBC 274, pp9861-9870, 1999, " \ "soluble FRS-2 compete with Shc for binding to TrkA with EC50" \ "requiring 2-5 fold exess of FRS-2." \ "" call /kinetics/TrkA/pTrkA_g/Shc_bind_pTrkA/notes LOAD \ "JBC 272, 6114-6121, 1999" \ "JBC 270, 15125-15129, 1995" \ "Shc PTB domain" \ "Kd = 0.19uM" \ "" call /kinetics/TrkA/pTrkA_g/pShc_bind_pTrkA/notes LOAD \ "JBC 272, 6114-6121, 1999" \ "JBC 270, 15125-15129, 1995" \ "Shc PTB domain" \ "Kd = 0.19uM" \ "" call /kinetics/TrkA/pTrkA_g/pShc_bind_Sos.Grb2[3]/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994, table on pg" \ "32623 indicates that this pathway accounts for about " \ "50% of the GEF activation. (88% - 39%). Error is large," \ "about 20%. Fig 1 is most useful in constraining rates." \ "" \ "Chook et al JBC 271:48 pp 30472, 1996 say that the Kd is" \ "0.2 uM for Shc binding to EGFR. The Kd for Grb direct binding" \ "is 0.7, so we'll ignore it." \ "---" \ "but existence of this pathway results persistent Ras activation " \ "even in the NGF stimulation." \ "I assume EGFR activation is necessary for the association of this complex." \ "oza" \ "kf = 0.5 -> 0, kb = 0.1 -> 0.1" \ "kf = 0, kb= 0.001666 (before mapk18c.g)" \ "Set Kd to 0.7uM. kf = 0.14286, kb = 0.1" \ "" call /kinetics/TrkA/pTrkA_g/pShc.Grb2_bind_pTrkA[1]/notes LOAD \ "JBC 272, 6114-6121, 1999" \ "JBC 270, 15125-15129, 1995" \ "Shc PTB domain" \ "Kd = 0.19uM" \ "" call /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph/notes LOAD \ "totaly assumption" \ "This adhoc dephosphorylation should be replaced by some" \ "Tyr phosphatase such as Shp." call /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[1]/notes LOAD \ "totaly assumption" \ "This adhoc dephosphorylation should be replaced by some" \ "Tyr phosphatase such as Shp." call /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[2]/notes LOAD \ "totaly assumption" \ "This adhoc dephosphorylation should be replaced by some" \ "Tyr phosphatase such as Shp." call /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[3]/notes LOAD \ "totaly assumption" \ "This adhoc dephosphorylation should be replaced by some" \ "Tyr phosphatase such as Shp." call /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[4]/notes LOAD \ "totaly assumption" \ "This adhoc dephosphorylation should be replaced by some" \ "Tyr phosphatase such as Shp." call /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[5]/notes LOAD \ "totaly assumption" \ "This adhoc dephosphorylation should be replaced by some" \ "Tyr phosphatase such as Shp." call /kinetics/TrkA/pTrkA_g/TrkA_Tyr_dephosph[6]/notes LOAD \ "totaly assumption" \ "This adhoc dephosphorylation should be replaced by some" \ "Tyr phosphatase such as Shp." call /kinetics/TrkA/pTrkA_endo_g/Internalization[1]/notes LOAD \ "kf = 0.005" call /kinetics/TrkA/pTrkA_endo_g/Internalization[4]/notes LOAD \ "gp140TrkA is cleard form the cell surface" \ "within 5min of 50ng/ml NGF treatment in PC12 cells." \ "J.Jullien et al., JBC 277, pp38700-38708, 2002." \ "Here I set Tau 120s." \ "" call /kinetics/TrkA/pTrkA_endo_g/Internalization[2]/notes LOAD \ "kf = 0.005" call /kinetics/TrkA/pTrkA_endo_g/Internalization[5]/notes LOAD \ "kf = 0.005" call /kinetics/TrkA/pTrkA_endo_g/Internalization/notes LOAD \ "kf = 0.005" call /kinetics/TrkA/pTrkA_endo_g/Internalization[3]/notes LOAD \ "kf = 0.005" call /kinetics/TrkA/pTrkA_endo_g/Shc_Tyr_phosphory[1]/notes LOAD \ "totaly assumption" \ "" call /kinetics/TrkA/pTrkA_endo_g/FRS2_Tyr_phosphory[1]/notes LOAD \ "totaly assumption" \ "" call /kinetics/TrkA/pTrkA_endo_g/pShc_bind_pTrkA/notes LOAD \ "JBC 272, 6114-6121, 1999" \ "JBC 270, 15125-15129, 1995" \ "Shc PTB domain" \ "Kd = 0.19uM" \ "" call /kinetics/TrkA/pTrkA_endo_g/Shc_bind_pTrkA/notes LOAD \ "JBC 272, 6114-6121, 1999" \ "JBC 270, 15125-15129, 1995" \ "Shc PTB domain" \ "Kd = 0.19uM" \ "" call /kinetics/TrkA/pTrkA_endo_g/pShc_bind_Sos.Grb2/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994, table on pg" \ "32623 indicates that this pathway accounts for about " \ "50% of the GEF activation. (88% - 39%). Error is large," \ "about 20%. Fig 1 is most useful in constraining rates." \ "" \ "Chook et al JBC 271:48 pp 30472, 1996 say that the Kd is" \ "0.2 uM for Shc binding to EGFR. The Kd for Grb direct binding" \ "is 0.7, so we'll ignore it." \ "---" \ "but existence of this pathway results persistent Ras activation " \ "even in the NGF stimulation." \ "I assume EGFR activation is necessary for the association of this complex." \ "oza" \ "kf = 0.5 -> 0, kb = 0.1 -> 0.1" \ "kf = 0, kb= 0.001666 (before mapk18c.g)" \ "Set Kd to 0.7uM. kf = 0.14286, kb = 0.1" \ "" call /kinetics/TrkA/pTrkA_endo_g/pTrkA.pFRS2.Crk.C3G_endo/TrkA-C3G_act/notes LOAD \ "see note in EGFR.C3G.c-Cbl_act." \ "" call /kinetics/TrkA/pTrkA_endo_g/pShc.Grb2_bind_pTrkA/notes LOAD \ "JBC 272, 6114-6121, 1999" \ "JBC 270, 15125-15129, 1995" \ "Shc PTB domain" \ "Kd = 0.19uM" \ "" call /kinetics/TrkA/pTrkA_endo_g/Internalization[6]/notes LOAD \ "kf = 0.005" call /kinetics/TrkA/kreac/notes LOAD \ "Kon and Koff of the high affinity site are," \ "Kon = 2.0e7/M/s, Koff = 6.4e-5/s, Kd = 2.8e-12M" \ "JBC 1994, v269, 6884-6891" \ "---" \ "I need smaller kf. See NGFR." \ "set Kf = 4/s" call /kinetics/TrkA/NGFR/notes LOAD \ "JBC 276, pp32687-32695, 2001" \ "TrkA-PC12 cells which over-expresses TrkA 20 fold excess than " \ "parental PC12 express 70,000 TrkA and 90,000 p75. They obtained " \ "Kd for high affinity site about 1.7e-11M using sf9 express both" \ "p75 and TrkA." \ "" \ "" call /kinetics/TrkA/stim_NGF_10ng[1]/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "" call /kinetics/TrkA/stim_NGF_1ng[1]/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "" call /kinetics/TrkA/stim_NGF_gate/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "" call /kinetics/TrkA/stim_NGF_5ng[1]/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "50ng/ml => 1.9nM" \ "" call /kinetics/MAPK/probe/pMEK_total/notes LOAD \ "" \ "" call /kinetics/MAPK/probe/non-pMEK_total/notes LOAD \ "" \ "" call /kinetics/MAPK/probe/non-pMEK_in-complex/notes LOAD \ "" \ "" call /kinetics/MAPK/probe/pMEK_in-complex/notes LOAD \ "" \ "" call /kinetics/MAPK/probe/ppMEK_in-complex/notes LOAD \ "" \ "" call /kinetics/MAPK/probe/ppMEK_total/notes LOAD \ "" \ "" call /kinetics/MAPK/MKP3/notes LOAD \ "MKP2 is modeled to act as a relatively steady," \ "unregulated phosphatase for controlling MAPK activity." \ "From Brondello et al JBC 272(2):1368-1376 (1997), the" \ "blockage of MKP-1 induction increases MAPK activity by" \ "no more than 2x. So this phosphatase will play the steady" \ "role and the fully stimulated MKP-1 can come up to the" \ "level of this steady level." \ "From Chu et al 1995 JBC 271(11):6497-6501 it looks like" \ "both MKP-1 and MKP-2 have similar activities in dephosphorylating" \ "ERK2. So I use the same enzymatic rates for both." \ "---" \ "MKP3 is said to be the most specific PPase for Erk1/2" \ "CoInit = 0.002 -> 0.02" \ "" call /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph/notes LOAD \ "22 Apr 2001: Based on MKP1 parms." \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. The only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies." \ "" \ "The rates are treated as the same as for MKP-1, based on" \ "Chu et al 1995 JBC 271(11):6497-6501" \ "---" \ "From Zhang.J, Zheng CF. and Zhang ZY, JBC 278 pp29901-29912, 2003" \ "the Kd of binding Erk2 and MKP3 is 0.170.04, so Km should be " \ "similar range. Km = 0.06667 -> 0.17" \ "---" \ "Zhang ZY, JBC 276 pp32382-32391, 2001" \ "They measured kinetics of MKP3, say Km for ppErk is 0.022uM, Vmax is " \ "0.084/sec. Km and Vmax for pErk are 0.034uM and 0.108/sec respectively." \ "" call /kinetics/MAPK/MKP3/MKP2-tyr_thr-deph_dppErk/notes LOAD \ "22 Apr 2001: Based on MKP1 parms." \ "The original kinetics have been modified to obey the k2 = 4 * k3 rule," \ "while keeping kcat and Km fixed. The only constraining" \ "data point is the time course of MAPK dephosphorylation, which this" \ "model satisfies." \ "" \ "The rates are treated as the same as for MKP-1, based on" \ "Chu et al 1995 JBC 271(11):6497-6501" \ "---" \ "From Zhang.J, Zheng CF. and Zhang ZY, JBC 278 pp29901-29912, 2003" \ "the Kd of binding Erk2 and MKP3 is 0.170.04, so Km should be " \ "similar range. Km = 0.06667 -> 0.17" \ "---" \ "Zhang ZY, JBC 276 pp32382-32391, 2001" \ "They measured kinetics of MKP3, say Km for ppErk is 0.022uM, Vmax is " \ "0.084/sec. Km and Vmax for pErk are 0.034uM and 0.108/sec respectively." \ "" call /kinetics/MAPK/MEK_PP.Erk2/notes LOAD \ "" \ "" call /kinetics/MAPK/MEK_P.Erk2/notes LOAD \ "" \ "" call /kinetics/MAPK/MEK.Erk2/notes LOAD \ "" \ "" call /kinetics/MAPK/MEK/notes LOAD \ "CoInit = 0.18uM from all117.g" \ "---" \ "In our SDS page experiments, only about a quarter of MEK exhibits " \ "mobility shift upon stimulation. " \ "---" \ "From Nishida et al., EMBO 16 pp1901-1908, 1997," \ "Fig4A indicates that the retio of Erk and MEK should be at least " \ "1:3 (MW of GST-KK(1-67) is roughly about 35kDa from Fig3B)." \ "But S.Kuroda says the ratio of endogenus Erk and MEK is up to 1:2." \ "So I inclease CoInit to 0.72uM, while Erk's is 0.36uM." \ "total MEK = 0.72uM, CoInit here is 0.36uM." call /kinetics/MAPK/MEK_PP/notes LOAD \ "" \ "" call /kinetics/MAPK/ppMEK_act_Erk2/notes LOAD \ "kf = 0.15, kb = 0" \ "---" \ "" call /kinetics/MAPK/ERK2/notes LOAD \ "CoInit = 0.36uM" \ "from acc4.g" \ "CoInit here is 0.01uM. Others are in MEK complex and in nuclear complex." call /kinetics/MAPK/kreac/notes LOAD \ "k1 = 16.304" \ "k2 = 0.6" \ "k3 = Vmax = 0.15" \ "km = 0.046" \ "" call /kinetics/MAPK/kreac[2]/notes LOAD \ "k1 = 16.304" \ "k2 = 0.6" \ "based on the enzymatic reaction which ppMEK phosphorylate Erk." \ "---" \ "From Nishida et al., EMBO 20 pp466-479, 2001," \ "the docking site for MEK is located on the opposit side" call /kinetics/MAPK/kreac[8]/notes LOAD \ "k1 = 16.304" \ "k2 = 0.6" \ "based on the enzymatic reaction which ppMEK phosphorylate Erk." call /kinetics/MAPK/ppErk_dimerize/notes LOAD \ "Erk dimerize upon phosphorylation; Kd = 7.5nM" \ "Cell 93, 605-615, 19989" \ "Though ppErk is known to form dimer with non-phospho Erk, I ignore it." call /kinetics/MAPK/PP2A/notes LOAD \ "CoInit = 0.16uM from all117.g" \ "---" \ "CoInit = 0.08uM oza" \ "" call /kinetics/MAPK/PP2A/dephosSer/notes LOAD \ "Vmax = 6" \ "-> Vmax = 3 oza" \ "" call /kinetics/MAPK/PP2A/dephosSer_pMEK.Erk2/notes LOAD \ "Vmax = 6" \ "-> Vmax = 3 oza" \ "" call /kinetics/MAPK/B-Raf/notes LOAD \ "CoInit = 0.2uM" \ "same as C-Raf" \ "---" \ "CoInit of Raf is much smaller than Mek and Erk (S.Kuroda)." \ "CoInit = 0.05" \ "" call /kinetics/MAPK/C-Raf/notes LOAD \ "CoInit = 0.2uM" \ "from all177.g" \ "---" \ "CoInit of Raf is much smaller than Mek and Erk (S.Kuroda)." \ "CoInit = 0.1" \ "" \ "" call /kinetics/MAPK/Rap1_B-Raf/ser/notes LOAD \ "same as Ras_B-Raf" \ "km = 0.16uM " \ "oza" \ "" call /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser/notes LOAD \ "same as Ras_B-Raf" \ "km = 0.16uM " \ "oza" \ "" call /kinetics/MAPK/Rap1_B-Raf/ser[1]/notes LOAD \ "same as Ras_B-Raf" \ "km = 0.16uM " \ "oza" \ "" call /kinetics/MAPK/Rap1_B-Raf/Rap1_B-Raf_ser[1]/notes LOAD \ "same as Ras_B-Raf" \ "km = 0.16uM " \ "oza" \ "" call /kinetics/MAPK/Ras_B-Raf/ser/notes LOAD \ "see all117.g" \ "---" \ "" call /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser/notes LOAD \ "see all117.g" \ "---" \ "km = 0.16uM -> 0.1uM" \ "oza" \ "" call /kinetics/MAPK/Ras_B-Raf/ser[1]/notes LOAD \ "see all117.g" \ "---" \ "" call /kinetics/MAPK/Ras_B-Raf/Ras_B-Raf_ser[1]/notes LOAD \ "see all117.g" \ "---" \ "km = 0.16uM -> 0.1uM" \ "oza" \ "" call /kinetics/MAPK/Ras_C-Raf/notes LOAD \ "Note that enz-subst complx are 'hidden'." call /kinetics/MAPK/Ras_C-Raf/ser/notes LOAD \ "Ras -> C-Raf is faster than Ras -> B-Raf." \ "So, I give larger km and faster Vmax than B-Raf." call /kinetics/MAPK/Ras_C-Raf/thr/notes LOAD \ "" \ "" call /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr/notes LOAD \ "" \ "" call /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser/notes LOAD \ "Ras -> C-Raf is faster than Ras -> B-Raf." \ "So, I give larger km and faster Vmax than B-Raf." call /kinetics/MAPK/Ras_C-Raf/thr[1]/notes LOAD \ "" \ "" call /kinetics/MAPK/Ras_C-Raf/ser[1]/notes LOAD \ "Ras -> C-Raf is faster than Ras -> B-Raf." \ "So, I give larger km and faster Vmax than B-Raf." call /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_ser[1]/notes LOAD \ "Ras -> C-Raf is faster than Ras -> B-Raf." \ "So, I give larger km and faster Vmax than B-Raf." call /kinetics/MAPK/Ras_C-Raf/Ras_C-Raf_thr[1]/notes LOAD \ "" \ "" call /kinetics/MAPK/Ras_bind_B-Raf/notes LOAD \ "see Ras_bind_C-Raf." \ "" call /kinetics/MAPK/Rap1_bind_B-Raf/notes LOAD \ "see Ras_bind_C-Raf." call /kinetics/MAPK/Ras_bind_C-Raf/notes LOAD \ "kf = 24, kb = 0.5 see all117.g" \ "---" \ "acc4.g uses kf = 60, kb = 0.5. Raf and Mek are said to form a complex" \ "with or without some scaffold proteins like MP1 and 14-3-3." \ "So, in-vitro experiment may not reflect in vivo kinetics." \ "With kd = 0.01, RasGTP.C-Raf can fully activate MEK. See MEK also." call /kinetics/Dok-RasGAP/dephospho_ppDok2/notes LOAD \ "assumption" \ "Kf is associated with (unknown)ppase activity, and" \ "Kb represents basal membrane localization of RasGAP." \ "" call /kinetics/Dok-RasGAP/Dok2/notes LOAD \ "Dok-R PTB domain affinity for ppEGFR phospho-peptides are found in" \ "Nina Jonse and Daniel Dumont, Curr Biol., Vol9 pp1057-1060, 1999." \ "Kd for Tyr1086 = 132nM," \ "Kd for Tyr1148 = 117nM." \ "" call /kinetics/FRS2_g/FRS2/notes LOAD \ "1" \ "" call /kinetics/EGFR_g/EGFR/notes LOAD \ "Lauffenburger and Linderman pg 255, refer to Starbuck and" \ "Lauffenburger 1992. They also say (pg 256) that about" \ "3K surface complexes should give mitogenic response." \ "---" \ "CoInit = 0.3uM" \ "oza" call /kinetics/EGFR_g/activate_EGFR/notes LOAD \ "This happens pretty fast. We see a response in the" \ "tyr phosph of Shc within 30 sec." \ "See Sasaoka et al JBC 269:51 pp 32621 1994 fig 1." \ "" \ " Lets treat this as " \ "a standard rec-ligand interaction, acting in under a" \ "sec, and give the phosphorylation a bit of time." \ "Affinity should be about 1 nM, from Lauffenburger and" \ "Linderman pg 257. " \ "Sims show 10x lower would be better." \ "---" \ "Fremch et al., 270, 4334-4340, JBC" \ " EGF Kon = 0.0630.02/nM/min" \ " Koff = 0.160.05/min" \ "" \ "DeWitt et al., 250, 305, Devl. Biol., 2002" \ " 125I-EGF Kon = 0.137/nM/min" \ " Koff = 0.178/min" \ " Kd = 1.37uM" \ "oza" \ "" call /kinetics/EGFR_g/EGF/notes LOAD \ "Mitogenic response occurs at about 2nM EGF according to fig" \ "in Lauffenburger and Linderman pg 257." call /kinetics/EGFR_g/dimerize_EGFR/notes LOAD \ "This step has to be quite strongly forward. We will bundle" \ "in a lot of more complex things for now, such as the" \ "dephosphorylation and release of ligand. The time course" \ "is estimated around 1 min for the forward step, and perhaps" \ "10 min for the backwards. Even tighter constraint: " \ "Shc is well phosphorylated within 30 sec. So this step should" \ "be about 10 sec. See Sasaoka et al JBC 269:51 3...." \ "---" \ "Kf=0.1 kb=0.02 -> kf=1 kb=0.02 oza" \ "" call /kinetics/EGFR_g/Tyr_phosphory/notes LOAD \ "totaly assumption" \ "" call /kinetics/EGFR_g/probe/non-ubiqEGFR*_total/EGFR_act_Dok2/notes LOAD \ "All phosphorylated EGFR possibly phosphorylate Dok2." \ "This implementation is a rough approximation, but for the " \ "case of high Km enzyme, means low specificity, it gives " \ "good approxymation." \ "---" \ "Dok-R directly bind to pT1086 and pT1148 of EGFR through PTB dimain" \ "with Kd of 130nM and 117nM respectively." \ "Current Biology 1999, 9, pp1057-1060." \ "Kd for TrkA is unknown." call /kinetics/EGFR_g/proto_EGFR/notes LOAD \ "Lauffenburger and Linderman pg 255, refer to Starbuck and" \ "Lauffenburger 1992. They also say (pg 256) that about" \ "3K surface complexes should give mitogenic response." \ "---" \ "CoInit = 0.3uM" \ "oza" call /kinetics/EGFR_g/EGFR_synthesis/notes LOAD \ "Kf = Kb = 0.0005 based on EGFR turn over time (assumption)." \ "---" \ "kf = kb = 0.0001 this seems to be nice." \ "To mimic LY294002, kf = kb = 0.01" call /kinetics/EGFR_g/pEGFR_g/Shc.ppEGFR/notes LOAD \ "Perhaps we should have the EGFR kinase activity on this." call /kinetics/EGFR_g/pEGFR_g/FRS2_Tyr_phosphory/notes LOAD \ "totaly assumption" \ "" call /kinetics/EGFR_g/pEGFR_g/Shc_phosphory[1]/notes LOAD \ "totaly assumption" \ "" call /kinetics/EGFR_g/pEGFR_g/pFRS2.Crk.C3G.pEGFR/EGFR-C3G_act/notes LOAD \ "MCB 1995, pp6746-6753" \ "Km = 10nM, Vmax = 0.0024/s" \ "" call /kinetics/EGFR_g/pEGFR_g/FRS2_bind_EGFR/notes LOAD \ "PTB domain of FRS2 can directly bind to tylosine phosphorylated EGFR." \ "Biol. Chem Vol384, pp1215-1226, 2003" \ "" \ "This binding conpetes with Shc." \ "JBC 274, pp9861-9870, 1999" \ "" \ "Kd is set smaller than Shc." \ "" call /kinetics/EGFR_g/pEGFR_g/Shc_bind_EGFR/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994 estimate that" \ "about 55% of EGFR is attached to Shc at the peak, between" \ "1 and 3 min after stim. Falls off fast after that, nearly" \ "baseline by 10 min. I judge that the falloff is largely " \ "limited by EGFR inactivation. Lets keep the rates fairly " \ "fast, say 30 sec. This gives kb = 0.033 and kf scaled down" \ "by 6e5 to keep units happy." \ "---" \ "Kd = 0.2uM. See Shc_bind_Sos.Grb2 " \ "oza" call /kinetics/EGFR_g/pEGFR_g/pShc_bind_EGFR/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994 estimate that" \ "about 55% of EGFR is attached to Shc at the peak, between" \ "1 and 3 min after stim. Falls off fast after that, nearly" \ "baseline by 10 min. I judge that the falloff is largely " \ "limited by EGFR inactivation. Lets keep the rates fairly " \ "fast, say 30 sec. This gives kb = 0.033 and kf scaled down" \ "by 6e5 to keep units happy." \ "---" \ "Kd = 0.2uM. See Shc_bind_Sos.Grb2 " \ "oza" call /kinetics/EGFR_g/pEGFR_g/pFRS2_bind_EGFR/notes LOAD \ "PTB domain of FRS2 can directly bind to tylosine phosphorylated EGFR." \ "Biol. Chem Vol384, pp1215-1226, 2003" \ "Kd is set smaller than Shc." call /kinetics/EGFR_g/pEGFR_g/pShc_bind_Sos.Grb2[1]/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994, table on pg" \ "32623 indicates that this pathway accounts for about " \ "50% of the GEF activation. (88% - 39%). Error is large," \ "about 20%. Fig 1 is most useful in constraining rates." \ "" \ "Chook et al JBC 271:48 pp 30472, 1996 say that the Kd is" \ "0.2 uM for Shc binding to EGFR. The Kd for Grb direct binding" \ "is 0.7, so we'll ignore it." \ "---" \ "but existence of this pathway results persistent Ras activation " \ "even in the NGF stimulation." \ "I assume EGFR activation is necessary for the association of this complex." \ "oza" \ "kf = 0.5 -> 0, kb = 0.1 -> 0.1" \ "kf = 0, kb= 0.001666 (before mapk18c.g)" \ "Set Kd to 0.7uM. kf = 0.14286, kb = 0.1" \ "" call /kinetics/EGFR_g/pEGFR_g/FRS2_bind_Crk/notes LOAD \ "SH2 domain of Crk" \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl/notes LOAD \ "kf = 2, kb = 0.05 " \ "assumption " \ "oza" \ "---" \ "kf = 0.025 kb = 0.01" \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc.Sos.Grb2.pEGFR.c-Cbl/notes LOAD \ "Perhaps we should also have the EGFR kinase activity on this." \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/pEGFR.pFRS2.Crk.C3G.c-Cbl/EGFR.C3G.c-Cbl_act/notes LOAD \ "MCB 1995, pp6746-6753" \ "Km = 10nM, Vmax = 0.0024/s" \ "---" \ "Vmax = 0.0024 -> 0.0048" \ "Vmax is too small, or C3G-Rap1GTP complex should act as raf activator," \ "I mean possibility that C3G is a Rap1GTP stabilizer rather than " \ "an enzyme. " \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_phosphory[2]/notes LOAD \ "totaly assumption" \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_Tyr_phosphory[1]/notes LOAD \ "totaly assumption" \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_Crk[1]/notes LOAD \ "SH2 domain of Crk" \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/pFRS2_bind_EGFR/notes LOAD \ "PTB domain of FRS2 can directly bind to tylosine phosphorylated EGFR." \ "Biol. Chem Vol384, pp1215-1226, 2003" \ "" \ "This binding conpetes with Shc." \ "JBC 274, pp9861-9870, 1999" \ "" \ "Kd is set smaller than Shc." \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[2]/notes LOAD \ "kf = 2, kb = 0.05 " \ "assumption " \ "oza" \ "---" \ "kf = 0.025 kb = 0.01" \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[3]/notes LOAD \ "kf = 2, kb = 0.05 " \ "assumption " \ "oza" \ "---" \ "kf = 0.025 kb = 0.01" \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[5]/notes LOAD \ "kf = 2, kb = 0.05 " \ "assumption " \ "oza" \ "---" \ "kf = 0.025 kb = 0.01" \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/bind_cbl[6]/notes LOAD \ "kf = 2, kb = 0.05 " \ "assumption " \ "oza" \ "---" \ "kf = 0.025 kb = 0.01" \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/Shc_bind_EGFR[1]/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994 estimate that" \ "about 55% of EGFR is attached to Shc at the peak, between" \ "1 and 3 min after stim. Falls off fast after that, nearly" \ "baseline by 10 min. I judge that the falloff is largely " \ "limited by EGFR inactivation. Lets keep the rates fairly " \ "fast, say 30 sec. This gives kb = 0.033 and kf scaled down" \ "by 6e5 to keep units happy." \ "---" \ "kf = 0.033333 -> 0.066666, then Kd = 1/2" \ "oza" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR[3]/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994 estimate that" \ "about 55% of EGFR is attached to Shc at the peak, between" \ "1 and 3 min after stim. Falls off fast after that, nearly" \ "baseline by 10 min. I judge that the falloff is largely " \ "limited by EGFR inactivation. Lets keep the rates fairly " \ "fast, say 30 sec. This gives kb = 0.033 and kf scaled down" \ "by 6e5 to keep units happy." \ "---" \ "Kd = 0.2uM. See Shc_bind_Sos.Grb2 " \ "oza" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_EGFR/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994 estimate that" \ "about 55% of EGFR is attached to Shc at the peak, between" \ "1 and 3 min after stim. Falls off fast after that, nearly" \ "baseline by 10 min. I judge that the falloff is largely " \ "limited by EGFR inactivation. Lets keep the rates fairly " \ "fast, say 30 sec. This gives kb = 0.033 and kf scaled down" \ "by 6e5 to keep units happy." \ "---" \ "Kd = 0.2uM. See Shc_bind_Sos.Grb2 " \ "oza" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/FRS2_bind_EGFR/notes LOAD \ "PTB domain of FRS2 can directly bind to tylosine phosphorylated EGFR." \ "Biol. Chem Vol384, pp1215-1226, 2003" \ "" \ "This binding conpetes with Shc." \ "JBC 274, pp9861-9870, 1999" \ "" \ "Kd is set smaller than Shc." \ "" call /kinetics/EGFR_g/pEGFR.c-Cbl_g/pShc_bind_Sos.Grb2[2]/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994, table on pg" \ "32623 indicates that this pathway accounts for about " \ "50% of the GEF activation. (88% - 39%). Error is large," \ "about 20%. Fig 1 is most useful in constraining rates." \ "" \ "Chook et al JBC 271:48 pp 30472, 1996 say that the Kd is" \ "0.2 uM for Shc binding to EGFR. The Kd for Grb direct binding" \ "is 0.7, so we'll ignore it." \ "---" \ "but existence of this pathway results persistent Ras activation " \ "even in the NGF stimulation." \ "I assume EGFR activation is necessary for the association of this complex." \ "oza" \ "kf = 0.5 -> 0, kb = 0.1 -> 0.1" \ "kf = 0, kb= 0.001666 (before mapk18c.g)" \ "Set Kd to 0.7uM. kf = 0.14286, kb = 0.1" \ "" call /kinetics/EGFR_g/pEGFR.ubiq_g/ubiquitination[2]/notes LOAD \ "kf = 1 kb = 0.25" \ "---" \ "kf = 0.016666" \ "---" \ "kf = 0.1666" \ "" call /kinetics/EGFR_g/pEGFR.ubiq_g/pShc.Sos.Grb2.pEGFR.c-Cbl.ubiq/notes LOAD \ "Perhaps we should also have the EGFR kinase activity on this." \ "" call /kinetics/EGFR_g/pEGFR.ubiq_g/EGFR-degradation[2]/notes LOAD \ "From our experiment (EGF with U0126 (4G10)), Tau seems to be 15min." \ "oza" \ "" call /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_Crk[1]/notes LOAD \ "SH2 domain of Crk" \ "" call /kinetics/EGFR_g/pEGFR.ubiq_g/pFRS2_bind_EGFR[1]/notes LOAD \ "PTB domain of FRS2 can directly bind to tylosine phosphorylated EGFR." \ "Biol. Chem Vol384, pp1215-1226, 2003" \ "Kd is set smaller than Shc." call /kinetics/EGFR_g/pEGFR.ubiq_g/FRS2_bind_EGFR[1]/notes LOAD \ "PTB domain of FRS2 can directly bind to tylosine phosphorylated EGFR." \ "Biol. Chem Vol384, pp1215-1226, 2003" \ "" \ "This binding conpetes with Shc." \ "JBC 274, pp9861-9870, 1999" \ "" \ "Kd is set smaller than Shc." \ "" call /kinetics/EGFR_g/pEGFR.ubiq_g/pShc_bind_Sos.Grb2[3]/notes LOAD \ "Sasaoka et al JBC 269:51 pp 32621 1994, table on pg" \ "32623 indicates that this pathway accounts for about " \ "50% of the GEF activation. (88% - 39%). Error is large," \ "about 20%. Fig 1 is most useful in constraining rates." \ "" \ "Chook et al JBC 271:48 pp 30472, 1996 say that the Kd is" \ "0.2 uM for Shc binding to EGFR. The Kd for Grb direct binding" \ "is 0.7, so we'll ignore it." \ "---" \ "but existence of this pathway results persistent Ras activation " \ "even in the NGF stimulation." \ "I assume EGFR activation is necessary for the association of this complex." \ "oza" \ "kf = 0.5 -> 0, kb = 0.1 -> 0.1" \ "kf = 0, kb= 0.001666 (before mapk18c.g)" \ "Set Kd to 0.7uM. kf = 0.14286, kb = 0.1" \ "" call /kinetics/EGFR_g/EGF[1]/notes LOAD \ "Mitogenic response occurs at about 2nM EGF according to fig" \ "in Lauffenburger and Linderman pg 257." call /kinetics/EGFR_g/EGF[2]/notes LOAD \ "Mitogenic response occurs at about 2nM EGF according to fig" \ "in Lauffenburger and Linderman pg 257." call /kinetics/EGFR_g/EGF[3]/notes LOAD \ "Mitogenic response occurs at about 2nM EGF according to fig" \ "in Lauffenburger and Linderman pg 257." call /kinetics/EGF_stim/stim_EGF_0.1ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "10ng/ml -> 1.613nM" \ "5ng/ml -> 0.808nM" \ "1ng/ml -> 0.1613nM" \ "0.5ng/ml -> 0.0808nM" \ "0.1ng/ml -> 0.01613nM" \ "" call /kinetics/EGF_stim/stim_EGF_1.5ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "10ng/ml -> 1.613nM" \ "5ng/ml -> 0.808nM" \ "1ng/ml -> 0.1613nM" call /kinetics/EGF_stim/stim_EGF_0.5ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "10ng/ml -> 1.613nM" \ "5ng/ml -> 0.808nM" \ "1ng/ml -> 0.1613nM" \ "0.5ng/ml -> 0.0808nM" call /kinetics/EGF_stim/stim_EGF_100ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "" call /kinetics/EGF_stim/stim_EGF_50ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "50ng/ml => 8.06nM" \ "" call /kinetics/EGF_stim/stim_EGF_10ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "10ng/ml -> 1.613nM" call /kinetics/EGF_stim/stim_EGF_5ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "10ng/ml -> 1.613nM" \ "5ng/ml -> 0.808nM" call /kinetics/EGF_stim/stim_EGF_1ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "10ng/ml -> 1.613nM" \ "5ng/ml -> 0.808nM" \ "1ng/ml -> 0.1613nM" call /kinetics/EGF_stim/stim_EGF_5ng[1]/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "10ng/ml -> 1.613nM" \ "5ng/ml -> 0.808nM" call /kinetics/EGF_stim/stim_EGF_10ng[1]/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "10ng/ml -> 1.613nM" call /kinetics/EGF_stim/stim_EGF_50ng[1]/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "50ng/ml => 8.06nM" \ "" call /kinetics/c-Cbl/notes LOAD \ "CoInit = 1uM" \ "assumption " \ "by oza" \ "---" \ "c-Cbl has a SH2 domain which recognizes pTyr1045 of EGFR.(Jikken Igaku" \ "Vol18 No1, 2000)" \ "" call /kinetics/EGF_ramp/notes LOAD \ "This group make a ramp stimulus." \ "" \ "Usage: " \ "Stim Level of stim_EGF should be set 3 times of final concentration required." \ "Kf of kreac should be set 1 / (3 * sloping period)." \ "Interpulse Delya of stim_off should be set (start time) + (sloping period)." \ "Baseline Level of multiplier can be used as a multiplier of concentration." \ "" \ "Ex. EGF increase to 1ng/ml in 5min after 100sec rest. " \ "stim_EGF: Stim Level = 0.1613nM," \ "stim_EGF: Interpulse Delay = 100sec," \ "multiplier: BaseLine = 1" \ "multiplier: Interpulse Delay = 100 + 5 * 60," \ "kreac: Kf = 1 / (3 * 5 * 60)." \ "" call /kinetics/EGF_ramp/stim_EGF_3ng/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "3ng/ml -> 0.4839nM" call /kinetics/EGF_ramp/GATE/notes LOAD \ "Mitogenic response occurs at about 2nM EGF according to fig" \ "in Lauffenburger and Linderman pg 257." call /kinetics/EGF_ramp/EGF[2]/notes LOAD \ "Use SUMTOTAL(pool to pool) to give stim to EGF." \ "" call /kinetics/EGF_ramp/kreac[10]/notes LOAD \ "slope period Kf" \ "120min 4.6296e-05" \ " 60min 9.2592e-05" \ " 30min 0.000185185" \ " 15min 0.00037037" \ " 5min 0.001111" \ " 2min 0.002777" \ "Kf = 1 / (3 * period(sec))" call /kinetics/EGF_ramp/EGF_pulse/notes LOAD \ "Mitogenic response occurs at about 2nM EGF according to fig" \ "in Lauffenburger and Linderman pg 257." call /kinetics/EGF_ramp/multiplier/notes LOAD \ "See note in EGF_ramp." call /kinetics/stim_EGF_auto/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 16.13nM" \ "10ng/ml -> 1.613nM" \ "5ng/ml -> 0.808nM" call /kinetics/stim_NGF_auto/notes LOAD \ "100ng/ml JBC, 276, 18169-18177, 2001" \ "-> 3.8nM" \ "50ng/ml => 1.9nM" \ "" call /kinetics/Rap1.GDP/notes LOAD \ "CoInit = 0.2uM" \ "oza" \ "" complete_loading